Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation

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Date
2010
Authors
To, Sarah
Rathjen, Peter
Keough, Rebecca
Rodda, Stephen
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Copyright: © 2010 To et al.
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To et al.
Abstract
CRTR-1 is a member of the CP2 family of transcription factors. Unlike other members of the family which are widely expressed, CRTR-1 expression shows specific spatio-temporal regulation. Gene targeting demonstrates that CRTR-1 plays a central role in the maturation and function of the salivary glands and the kidney. CRTR-1 has also recently been identified as a component of the complex transcriptional network that maintains pluripotency in embryonic stem (ES) cells. CRTR-1 was previously shown to be a repressor of transcription. We examine the activity of CRTR-1 in ES and other cells and show that CRTR-1 is generally an activator of transcription and that it modulates the activity of other family members, CP2, NF2d9 and altNF2d9, in a cell specific manner. We also demonstrate that CRTR-1 activity is regulated by sumoylation at a single major site, residue K30. These findings imply that functional redundancy with other family members may mask important roles for CRTR-1 in other tissues, including the blastocyst stage embryo and embryonic stem cells.
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Copyright: © 2010 To et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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To, S., Rodda, S., Rathjen, P. and Keough, R. (2010). Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation. PLoS One, 5(7 e11702) pp. 1-13.