Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation

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To, Sarah
Rathjen, Peter
Keough, Rebecca
Rodda, Stephen
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Copyright: © 2010 To et al.
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To et al.
CRTR-1 is a member of the CP2 family of transcription factors. Unlike other members of the family which are widely expressed, CRTR-1 expression shows specific spatio-temporal regulation. Gene targeting demonstrates that CRTR-1 plays a central role in the maturation and function of the salivary glands and the kidney. CRTR-1 has also recently been identified as a component of the complex transcriptional network that maintains pluripotency in embryonic stem (ES) cells. CRTR-1 was previously shown to be a repressor of transcription. We examine the activity of CRTR-1 in ES and other cells and show that CRTR-1 is generally an activator of transcription and that it modulates the activity of other family members, CP2, NF2d9 and altNF2d9, in a cell specific manner. We also demonstrate that CRTR-1 activity is regulated by sumoylation at a single major site, residue K30. These findings imply that functional redundancy with other family members may mask important roles for CRTR-1 in other tissues, including the blastocyst stage embryo and embryonic stem cells.
Copyright: © 2010 To et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
To, S., Rodda, S., Rathjen, P. and Keough, R. (2010). Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation. PLoS One, 5(7 e11702) pp. 1-13.