Method for the generation and cultivation of functional three-dimensional mammary constructs without exogenous extracellular matrix

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dc.contributor.author Harding, Frances Jane
dc.contributor.author Timmins, Nicholas E
dc.contributor.author Smart, Chanel E
dc.contributor.author Brown, Matthew A
dc.contributor.author Nielsen, Lars K
dc.date.accessioned 2014-09-30T06:11:59Z
dc.date.available 2014-09-30T06:11:59Z
dc.date.issued 2005 en
dc.description.abstract During puberty, pregnancy, lactation and post-lactation, breast tissue undergoes extensive remodelling and the disruption of these events can lead to cancer. In vitro studies of mammary tissue and its malignant transformation regularly employ mammary epithelial cells cultivated on matrigel or floating collagen rafts. In these cultures, mammary epithelial cells assemble into three-dimensional structures resembling in vivo acini. We present a novel technique for generating functional mammary constructs without the use of matrix substitutes.
dc.identifier.citation Timmins, N.E., Harding, F.J., Smart, C., Brown, M.A. and Nielsen, K. (2005). Method for the generation and cultivation of functional three-dimensional mammary constructs without exogenous extracellular matrix. Cell and Tissue Research, 320(1) pp. 207-210. en
dc.identifier.doi https://doi.org/10.1007/s00441-004-1064-6 en
dc.identifier.issn 0302-766X en
dc.identifier.rmid 2006019214 en
dc.identifier.uri http://hdl.handle.net/2328/33069
dc.subject.forgroup 1116 Medical Physiology en
dc.title Method for the generation and cultivation of functional three-dimensional mammary constructs without exogenous extracellular matrix en
dc.type Article en
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