Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing
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Date
2012-01-19
Authors
LaPointe, Lawrence C
Pedersen, Susanne K
Dunne, Robert
Brown, Glenn S
Pimlott, Letitia
Gaur, Snigdha
McEvoy, Aidan
Thomas, Melissa
Wattchow, David Anthony
Molloy, Peter L
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Rights Holder
(C) 2012 LaPointe et al.
Abstract
Results: Genome-wide analysis uncovered reproducible gene expression signatures for both adenomas and cancers
compared to controls. 386/489 (79%) of the adenoma and 439/529 (83%) of the adenocarcinoma biomarkers were validated
in independent tissues. We also identified genes differentially expressed in adenomas compared to cancer. KIAA1199 was
selected for further analysis based on consistent up-regulation in neoplasia, previous studies and its interest as an
uncharacterized gene. Plasma KIAA1199 RNA levels were significantly higher in patients with either cancer or adenoma (31/
40) compared to neoplasia-free controls (6/20).
Description
Keywords
Colorectal cancer, Biomarker validation
Citation
LaPointe, L.C., Pedersen, S.K., Dunne, R., Brown, G.S., Pimlott, L., Gaur, S., McEvoy, A., Thomas, M., Wattchow, D., Molloy, P.L. and Young, G.P., 2012. Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing. PLoS ONE 7(1): e29059.