Anabolic steroids for rehabilitation after hip fracture in older people
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Date
2014-10-06
Authors
Farooqi, Vaqas
van den Berg, Maayken
Cameron, Ian D
Crotty, Maria
Journal Title
Journal ISSN
Volume Title
Publisher
Cochrane Database of Systematic Reviews
Rights
Copyright © 2014 The Cochrane Collaboration.
Rights Holder
The Cochrane Collaboration.
Abstract
Background
Hip fracture occurs predominantly in older people, many of whom are frail and undernourished. After hip fracture surgery and rehabilitation, most patients experience a decline in mobility and function. Anabolic steroids, the synthetic derivatives of the male hormone testosterone, have been used in combination with exercise to improve muscle mass and strength in athletes. They may have similar effects in older people who are recovering from hip fracture.
Objectives
To examine the effects (primarily in terms of functional outcome and adverse events) of anabolic steroids after surgical treatment of hip fracture in older people.
Search methods
We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (10 September 2013), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2013 Issue 8), MEDLINE (1946 to August Week 4 2013), EMBASE (1974 to 2013 Week 36), trial registers, conference proceedings, and reference lists of relevant articles. The search was run in September 2013.
Selection criteria
Randomised controlled trials of anabolic steroids given after hip fracture surgery, in inpatient or outpatient settings, to improve physical functioning in older patients with hip fracture.
Data collection and analysis
Two review authors independently selected trials (based on predefined inclusion criteria), extracted data and assessed each study's risk of bias. A third review author moderated disagreements. Only very limited pooling of data was possible. The primary outcomes were function (for example, independence in mobility and activities of daily living) and adverse events, including mortality.
Description
Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
This review is made available in accordance with Cochrane Database of Systematic Review's repositories policy
Keywords
Hip fracture, older people, undernourished, hip fracture surgery, rehabilitation, Anabolic steroids
Citation
Farooqi, V., van den Berg, M. E., Cameron, I. D., & Crotty, M. (2014). Anabolic steroids for rehabilitation after hip fracture in older people. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd008887.pub2