Contrast and glare testing in keratoconus and after penetratin keratoplasty

dc.contributor.authorPesudovs, Konrad
dc.contributor.authorSchoneveld, P
dc.contributor.authorSeto, R J
dc.contributor.authorCoster, Douglas John
dc.description.abstractAIM: To compare the performance of keratoconus, penetrating keratoplasty (PK), and control subjects on clinical tests of contrast and glare vision, to determine whether differences in vision were independent of visual acuity (VA), and thereby establish which vision tests are the most useful for outcome studies of PK for keratoconus. METHODS: All PK subjects had keratoconus before grafting and no subjects had any other eye disease. The keratoconus (n = 11, age 35.0 (SD 11.1) years), forme fruste keratoconus (n = 6, 33.0 (13.0)), PK (n = 21, 41.2 (7.9)), and control (n = 24, 33.7 (8.6)) groups were similar in age. Vision testing, conducted with optimal refractive correction in place, included low contrast visual acuity (LCVA) and Pelli-Robson contrast sensitivity (PRCS) both with and without glare, as well as VA. RESULTS: Normal subjects saw better than PK subjects who in turn saw better than keratoconus subjects on all raw measures. However, when adjusted for VA, the normal group only saw significantly better than the keratoconus group on LCVA (low contrast loss 0.05 (0.04) v 0.15 (0.12), F(2,48) = 6.16; p<0.01, post hoc Sheffe p<0.05), and the decrements to glare were no worse than for normals. The forme fruste keratoconus group were indistinguishable from normals on all measures. CONCLUSIONS: PK subjects have superior vision to keratoconus subjects, but not as good as normal subjects. Including mild keratoconus subjects within a keratoconus group could confound these differences in vision. While VA is an excellent test for comparing normal, keratoconus and PK groups, additional information can be provided by LCVA and PRCS, but not by glare testing. Outcomes research into keratoconus management should include a measure in the contrast domain.en
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dc.identifier.citationK Pesudovs, P Schoneveld, R J Seto and DJ Coster 2004. Contrast and glare testing in keratoconus and after penetrating keratoplasty. 'British Journal of Ophthalmology', May, Vol 88, No 5, 653-7en
dc.identifier.issn0007 1161
dc.oaire.license.condition.licenseIn Copyright
dc.publisherBMJ Publishing Group -
dc.subjectContrast Sensitivityen
dc.subjectKeratoplasty, Penetratingen
dc.subjectPostoperative Perioden
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectTreatment Outcomeen
dc.subjectVision Testsen
dc.subjectVisual Acuityen
dc.subject.otherAustralian Standard Research Classification 321016 Ophthalmology and Vision Scienceen
dc.titleContrast and glare testing in keratoconus and after penetratin keratoplastyen
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