Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology
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Date
2017-12-27
Authors
Jami, Sina
Erickson, Andelain
Brierley, Stuart M
Vetter, Irina
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Rights
© 2017 by the authors.
Rights Holder
the authors.
Abstract
Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating predators or prey. While some venoms are of relatively simple composition, many contain hundreds to thousands of individual components with distinct pharmacological activity. Pain-inducing or “algesic” venom compounds have proven invaluable to our understanding of how physiological nociceptive neural networks operate. In this review, we present an overview of some of the diverse nociceptive pathways that can be modulated by specific venom components to evoke pain. View Full-Text
Description
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Keywords
animal venom, pain, ASIC, sodium channel, TRP channel, pore forming toxin
Citation
Jami, S.; Erickson, A.; Brierley, S.M.; Vetter, I. Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology. Toxins 2018, 10, 15.