Controlled drug delivery from composites of nanostructured porous silicon and poly(L-lactide)

Simple item page
dc.contributor.author McInnes, Steven James
dc.contributor.author Irani, Yazad
dc.contributor.author Williams, Keryn Anne
dc.contributor.author Voelcker, Nicolas Hans
dc.date.accessioned 2013-08-26T02:05:00Z
dc.date.available 2013-08-26T02:05:00Z
dc.date.issued 2012-03-06
dc.description.abstract Porous silicon (pSi) and poly(l-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination of a pliable and soft polymeric material with a hard inorganic porous material of high drug loading capacity may engender improved control over degradation and drug release profiles and be beneficial for the preparation of advanced drug delivery devices and biodegradable implants or scaffolds. Materials & methods: In this work, three different pSi and PLLA composite formats were prepared. The first format involved grafting PLLA from pSi films via surface-initiated ring-opening polymerization (pSi–PLLA [grafted]). The second format involved spin coating a PLLA solution onto oxidized pSi films (pSi–PLLA [spin-coated]) and the third format consisted of a melt-cast PLLA monolith containing dispersed pSi microparticles (pSi–PLLA [monoliths]). The surface characterization of these composites was performed via infrared spectroscopy, scanning electron microscopy, atomic force microscopy and water contact angle measurements. The composite materials were loaded with a model cytotoxic drug, camptothecin (CPT). Drug release from the composites was monitored via fluorimetry and the release profiles of CPT showed distinct characteristics for each of the composites studied. Results: In some cases, controlled CPT release was observed for more than 5 days. The PLLA spin coat on pSi and the PLLA monolith containing pSi microparticles both released a CPT payload in accordance with the Higuchi and Ritger–Peppas release models. Composite materials were also brought into contact with human lens epithelial cells to determine the extent of cytotoxicity. Conclusion: We observed that all the CPT containing materials were highly efficient at releasing bioactive CPT, based on the cytotoxicity data. en
dc.description.sponsorship Support from the Australian Research Council (Australian Capital Territory, Australia), Bellberry Ltd. (Dulwich, South Australia), Flinders University (Adelaide, Australia) and the National Health and Medical Research Council (Canberra, Australia) is gratefully acknowledged. en
dc.identifier.citation McInnes, S.J.P., Irani, Y., Williams, K.A. and Voelcker, N.H., 2012. Controlled drug delivery from composites of nanostructured porous silicon and poly(Llactide). Nanomedicine, 7(7), 995-1016. en
dc.identifier.doi https://doi.org/10.2217/nnm.11.176 en
dc.identifier.issn 1743-5889
dc.identifier.uri http://hdl.handle.net/2328/26977
dc.language.iso en
dc.publisher Future Medicine en
dc.relation http://purl.org/au-research/grants/nhmrc/1002044 en
dc.relation http://purl.org/au-research/grants/nhmrc/595901 en
dc.relation.grantnumber NHMRC/1002044 en
dc.relation.grantnumber NHMRC/595901 en
dc.rights Future Medicine may permit authors to archive their contributions on non-commercial websites. This can be either via their own website or via their institution’s or funding body’s online repository or archive, following an appropriate embargo period. This policy varies depending on the type of publication and permission must be sought before archiving. en
dc.rights.holder © 2012 Future Medicine Ltd en
dc.rights.license In Copyright
dc.subject Opthalmology en
dc.subject Glaucoma en
dc.title Controlled drug delivery from composites of nanostructured porous silicon and poly(L-lactide) en
dc.type Article en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
McInnes Controlled.pdf
Size:
4.89 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.73 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Ophthalmology, Eye and Vision Research Collected Works
 Flinders Open Access Research
 Keryn Williams
 National Health and Medical Research Council (NHMRC)