Bioactive mimetics of conotoxins and other venom peptides
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Date
2015-10-16
Authors
Duggan, Peter
Tuck, Kellie L
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Rights
© 2015 by the authors
Rights Holder
The authors
Abstract
Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA
found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode of delivery and narrow therapeutic window cause complications for patients. This review will summarize progress in the development of small molecule, non-peptidic mimics of Conotoxins and a small number of other venom peptides. This will include a description of how some of the initially designed mimics have been modified to improve their drug-like properties.
Description
© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Keywords
venom peptides, toxins, conotoxins, peptidomimetics, N-type calcium channel, Cav2.2
Citation
Duggan, P., & Tuck, K. (2015). Bioactive Mimetics of Conotoxins and other Venom Peptides. Toxins, 7(10), 4175–4198. https://doi.org/10.3390/toxins7104175