Anterior 90° partial vs Nissen fundoplication - 5 year follow-up of a single-centre randomised trial

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Watson, David Ian
Devitt, Peter G
Smith, Lorelle T
Jamieson, Glyn G
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© 2012 Springer
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Introduction Nissen fundoplication can be followed by side effects, and this has driven modifications, including partial fundoplications. We previously reported early outcomes from a randomised trial of Nissen vs anterior 900 partial fundoplication. This paper reports 5 year follow-up outcomes to determine whether anterior 900 fundoplication achieves a satisfactory longer term outcome. Methods From February 1999 to August 2003, 79 patients were randomized to Nissen vs. Anterior 90o fundoplication. Patients were followed yearly using a standardized clinical questionnaire which included symptom scores to assess heartburn, dysphagia, other post-fundoplication side effects, and overall satisfaction with the outcome. Five year clinical outcomes were analysed. Results Seventy four patients were available for follow-up at 5 years. There were no significant differences for: heartburn or satisfaction, although more patients used antisecretory medication after anterior 900 fundoplication (29.7% vs 8.1%). Dysphagia was greater after Nissen fundoplication when measured by an analog score for solid food and a composite dysphagia score. Symptoms of bloating were more common following Nissen fundoplication (80.0% vs 32.4%), and less patients could eat a normal diet (78.4% vs. 94.6%). Re-operation was undertaken in 4 patients after Nissen fundoplication (dysphagia – 3, hiatus hernia -1) vs. 3 after anterior 900 fundoplication (recurrent reflux – 3). Conclusions At 5 years, Anterior 900 partial fundoplication was associated with less side effects, offset by greater use of antisecretory medication. Reflux symptoms and overall satisfaction were similar to Nissen fundoplication. Laparoscopic anterior 900 partial fundoplication is an effective treatment for gastro-esophageal reflux.
Author version made available in accordance with the publisher's policy.
Fundoplication, Gastroesophageal reflux
Watson DI, Devitt PG, Smith L, Jamieson GG. Anterior 90° partial vs Nissen fundoplication - 5 year follow-up of a single-centre randomised trial. Journal of Gastrointestinal Surgery. 2012 Sep;16(9):1653-8.