Epigenetic effects on eye diseases

dc.contributor.author Hewitt, Alex W
dc.contributor.author Wang, Jie Jin
dc.contributor.author Liang, Helena
dc.contributor.author Craig, Jamie E
dc.date.accessioned 2013-08-29T07:45:27Z
dc.date.available 2013-08-29T07:45:27Z
dc.date.issued 2012-04
dc.description This article is published by Informa Healthcare. Under Informa's copyright, authors are not permitted to make their work available in an institutional repository. en
dc.description.abstract Epigenetics is the process by which patterns of gene expression are modified in a mitotically heritable manner. However, these epigenetic variations are not attributable to changes in the primary nucleotide sequence within DNA. In this review, the emerging field of epigenetics is introduced and the potential role it may have in the manifestation of common ocular disease is explored. Given our current understanding of the genetic, environmental and phenotypic profiles, it is probable that stochastic epigenetic effects have an important role in the pathogenesis of age-related macular degeneration, glaucoma, cataract and myopia. The ability to profile individuals at an epigenetic level offers a novel means to intimately dissect gene–environment interactions. en
dc.identifier.citation Hewitt, A.W., Wang, J.J., Liang, H. and Craig, J.E., 2012. Epigenetic effects on eye diseases. Expert Review of Ophthalmology, 7(2), 127-134. en
dc.identifier.doi https://doi.org/10.1586/eop.12.11 en
dc.identifier.uri http://hdl.handle.net/2328/27022
dc.language.iso en
dc.publisher Informa Plc en
dc.rights Copyright © 2013 Informa Plc. All rights reserved. en
dc.rights.holder Informa Plc en
dc.subject Opthalmology en
dc.title Epigenetic effects on eye diseases en
dc.type Article en
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