Real-world use of fidaxomicin in a large UK tertiary hospital: how effective is it for treating recurrent disease?
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Date
2018-05-07
Authors
Enoch, David A
Santos, Reem
Phillips, Cameron J
Micallef, Christianne
Murphy, Michael E
Aliyu, Sani Hussein
Massey, Dunecan C O
Brown, Nicholas M
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Rights
© 2018 The Healthcare Infection Society. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Rights Holder
© 2018 The Healthcare Infection Society. Published by Elsevier Ltd.
Abstract
All courses of fidaxomicin use in the study hospital were reviewed. It was used for first recurrence (six times), second recurrence (eight times) and one case of third recurrence. One patients received fidaxomicin as first-line treatment. Eight patients initially responded to therapy; of these, three patients were asymptomatic at 90 days, three patients remained asymptomatic at 30 days, and two patients had recurrences five and nine days after stopping therapy. Four patients failed to respond; of these, two patients required faecal transplantation and one patient required a colectomy. Two patients deteriorated and two patients died. Fidaxomicin was well tolerated. These findings suggest that the utility of fidaxomicin at this stage of infection is unclear.
Description
This manuscript version is made available under the CC-BY-NC-ND 4.0 license:
http://creativecommons.org/licenses/by-nc-nd/4.0/ which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. This author accepted manuscript is made available following 12 month embargo from date of publication (May 2018) in accordance with the publisher’s archiving policy
Keywords
Clostridium difficile, Fidaxomicin, Recurrence
Citation
Enoch, D. A., Santos, R., Phillips, C. J., Micallef, C., Murphy, M. E., Aliyu, S. H., … Brown, N. M. (2018). Real-world use of fidaxomicin in a large UK tertiary hospital: how effective is it for treating recurrent disease? Journal of Hospital Infection, 100(2), 142–146.