The Homeobox Transcription Factor Barx2 Regulates Plasticity of Young Primary Myofibers

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dc.contributor.author Barro, Marietta
dc.contributor.author Hulin, Julie-Ann
dc.contributor.author Walcott, Elizabeth C
dc.contributor.author Delgado, J
dc.contributor.author Makarenkova, Helen
dc.contributor.author Meech, Robyn
dc.contributor.author Gomez, Mariana
dc.contributor.author Woolley, Christopher
dc.date.accessioned 2014-09-30T06:04:21Z
dc.date.available 2014-09-30T06:04:21Z
dc.date.issued 2010 en_US
dc.description Copyright: © 2010 Meech et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en
dc.description.abstract Adult mammalian muscle retains incredible plasticity. Muscle growth and repair involves the activation of undifferentiated myogenic precursors called satellite cells. In some circumstances, it has been proposed that existing myofibers may also cleave and produce a pool of proliferative cells that can re-differentiate into new fibers. Such myofiber dedifferentiation has been observed in the salamander blastema where it may occur in parallel with satellite cell activation. Moreover, ectopic expression of the homeodomain transcription factor Msx1 in differentiated C2C12 myotubes has been shown to induce their dedifferentiation. While it remains unclear whether dedifferentiation and redifferentiaton occurs endogenously in mammalian muscle, there is considerable interest in induced dedifferentiation as a possible regenerative tool. en
dc.identifier.citation Meech, R., Gomez, M., Woolley, C., Barro, M., Hulin, J., Walcott, E.C., et al. (2010). The Homeobox Transcription Factor Barx2 Regulates Plasticity of Young Primary Myofibers. PLoS One, 5(7) pp. 1-9. en
dc.identifier.doi https://doi.org/10.1371/journal.pone.0011612 en
dc.identifier.issn 1932-6203
dc.identifier.rmid 2006019546
dc.identifier.uri http://hdl.handle.net/2328/31800
dc.language.iso en
dc.oaire.license.condition.license CC-BY
dc.rights Copyright: © 2010 Meech et al. en
dc.rights.holder Meech et al. en
dc.subject.forgroup 0601 Biochemistry and Cell Biology en
dc.title The Homeobox Transcription Factor Barx2 Regulates Plasticity of Young Primary Myofibers en
dc.type Article en
local.contributor.authorOrcidLookup Hulin, Julie-Ann: https://orcid.org/0000-0003-4886-0416 en_US
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