Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain

Loading...
Thumbnail Image
Date
2010-08-26
Authors
Brierley, Stuart M
Hughes, Patrick A
Harrington, Ann Chrystine
Rychkov, Grigori Y
Blackshaw, L Ashley
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Rights
© 2010 by the authors; licensee MDPI, Basel, Switzerland.
Rights Holder
the authors
Abstract
We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas arise. However, for patients with organic and functional bowel disorders pain is an unpleasant and often debilitating reminder. Furthermore, chronic pain still represents a large unmet need for clinical treatment. Consequently, chronic pain has a considerable economic impact on health care systems and the afflicted individuals. In order to address this need we must understand how symptoms are generated within the gut, the molecular pathways responsible for generating these signals and how this process changes in disease states. View Full-Text
Description
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Keywords
TRPA1, TRPV4, TRPV1, ASICs, NaV and KV channels, chronic visceral pain (CVP), visceral pain
Citation
Brierley, S.M.; Hughes, P.A.; Harrington, A.M.; Rychkov, G.Y.; Blackshaw, L.A. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals 2010, 3, 2768-2798.