In vivo targeted therapy of gastric tumors via the mechanical rotation of a flower-like Fe3O4@Au nanoprobe under an alternating magnetic field

dc.contributor.author Yin, T
dc.contributor.author Wu, H
dc.contributor.author Zhang, Q
dc.contributor.author Gao, G
dc.contributor.author Shapter, Joseph George
dc.contributor.author Shen, Y
dc.contributor.author He, Q
dc.contributor.author Huang, P
dc.contributor.author Qi, W
dc.contributor.author Zhang, Chunlei
dc.contributor.author Yang, Yuming
dc.contributor.author Cui, D
dc.date.accessioned 2017-08-18T00:01:49Z
dc.date.available 2017-08-18T00:01:49Z
dc.date.issued 2017-07-14
dc.description This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. en
dc.description.abstract Owing to their hypotoxicity, great spatial resolution and tomographic properties, Fe3O4 nanoparticles (NPs) are becoming one of the most promising materials for noninvasive biological imaging and shape-dependent therapeutic agents for malignant tumor therapy. Conventional spherical NPs are unable to effectively destroy cellular structure in therapy and thus result in tumors with a high risk of drug resistance. Herein we developed a novel flower-like targeting Fe3O4@Au-HPG-Glc nanoprobe (thiol-containing hyperbranched polyglycerol (HPG); 4-aminophenyl β-D-glucopyranoside (Glc)) that can enhance magnetic resonance imaging (MRI) for cancer therapy. With the guidance of a targeting molecule, Fe3O4@Au-HPG-Glc nanoprobes can precisely target tumor cells. Under an alternating magnetic field (AMF), the flower-like Fe3O4@Au-HPG-Glc nanoprobes can rotate along the central axis of the core to substantially destroy tumor cells by damaging the nucleus or cell membrane. Our results showed that this shape-dependent therapeutic agent-based strategy had remarkable efficacy for MRI-guided tumor therapy. Furthermore, the inhibition of tumor growth in tumor-bearing mice was up to approximately 47.3% on the twelfth day of treatment compared with the level of inhibition in a blank group. Different from other reported methods for cancer therapy, our proposed AMF-dependent targeted cancer therapy is a novel strategy that can potentially reduce drug resistance in gastric tumors. en
dc.identifier.citation Yin, T., Wu, H., Zhang, Q., Gao, G., Shapter, J. G., Shen, Y., … Cui, D. (2017). In vivo targeted therapy of gastric tumors via the mechanical rotation of a flower-like Fe3O4@Au nanoprobe under an alternating magnetic field. NPG Asia Materials, 9(7), e408. https://doi.org/10.1038/am.2017.117 en
dc.identifier.doi https://doi.org/10.1038/am.2017.117 en
dc.identifier.issn 1884-4057
dc.identifier.uri http://hdl.handle.net/2328/37419
dc.language.iso en
dc.publisher Nature Publishing Group en
dc.rights Copyright (C) The Author(s) 2017 en
dc.rights.holder The Author(s) en
dc.rights.license CC-BY
dc.subject Fe3O4 nanoparticles en
dc.subject noninvasive biological imaging en
dc.subject alternating magnetic field en
dc.subject hypotoxicity en
dc.title In vivo targeted therapy of gastric tumors via the mechanical rotation of a flower-like Fe3O4@Au nanoprobe under an alternating magnetic field en
dc.type Article en
local.contributor.authorOrcidLookup Shapter, Joseph George: https://orcid.org/0000-0002-4000-2751 en_US
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