Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice
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Date
2018-02-05
Authors
Xie, Vicki
Tong, Daochen
Wallington-Beddoe, Craig T
Bradstock, Kenneth F
Bendall, Linda J
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Rights
© The Author(s) 2018
Rights Holder
The Author(s)
Abstract
Background
Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL).
Methods
In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF.
Results
Mice lacking ARF and SphK2 had a significantly reduced incidence of ALL compared mice with wild type SphK2.
Conclusions
These results show that the role of SphK2 in ALL development is not limited to BCR/ABL1 driven disease extending the potential use of inhibitors of this enzyme to ALL patients whose disease have driver mutations other than BCR/ABL1."
Description
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Keywords
Acute lymphoblastic leukemia, Sphingosine kinase 2, Mouse models
Citation
Xie, V., Tong, D., Wallington-Beddoe, C. T., Bradstock, K. F., & Bendall, L. J. (2018). Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice. Biomarker Research, 6(1). https://doi.org/10.1186/s40364-018-0120-4