Effects of α-lipoic acid on growth performance, body composition, antioxidant status and lipid catabolism of juvenile Chinese mitten crab Eriocheir sinensis fed different lipid percentage

dc.contributor.author Xu, Chang
dc.contributor.author Li, Erchao
dc.contributor.author Liu, Shuang
dc.contributor.author Huang, Zhipeng
dc.contributor.author Qin, Jianguang
dc.contributor.author Chen, Li Qiao
dc.date.accessioned 2017-10-25T02:34:27Z
dc.date.available 2017-10-25T02:34:27Z
dc.date.issued 2017-09-28
dc.description This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 24 month embargo from date of publication (Sept 2017) in accordance with the publisher’s archiving policy en
dc.description.abstract This study evaluates the effects of dietary lipid percentage (7% and 13%) on growth performance, body composition, antioxidative status and hepatopancreas lipid catabolism of Chinese mitten crab Eriocheir sinensis. Each lipid diet was supplemented with three concentrations of α-lipoic acid at 0, 700 and 1400 mg/kg, and fed to E. sinensis juveniles for eight weeks. The weight gain and specific growth rate of crabs fed the diets supplemented with α-LA were significantly higher than those fed the control diet without α-LA, regardless of dietary lipid percentage. The α-LA significantly increased lipid accumulation in the whole body and hepatopancreas in a dose-dependent manner. Crabs fed 13% lipid showed a significantly higher hepatosomatic index than those fed 7% lipid. The mRNA expressions of triacylglycerol lipase and intracellular lipase increased with the increase of α-LA concentration in crabs fed 7% lipid. No significant difference was found in the CPT-1 mRNA expression among all treatments. The α-LA supplementation at 1400 mg/kg significantly improved oxidative stress due to lipid accumulation in the hepatopancreas of crabs fed 7% lipid as indicated by the high activity of superoxide dismutase and glutathione peroxidase and a low level of malondialdehyde. The diet with 13% lipid increased the lipid content in the hepatopancreas but suppressed glutathione peroxidase. Meanwhile, the total antioxidant capacity increased with the increase of α-LA concentration in crabs fed 13% lipid. This study indicates that α-LA supplementation can improve growth performance and accelerate lipid accumulation in the hepatopancreas by increasing lipid utilization efficiency. Furthermore, α-LA can relieve hepatopancreas oxidative damage induced by lipid accumulation and improve the health of E. sinensis. en
dc.identifier.citation Xu, C., Li, E., Liu, S., Huang, Z., Qin, J. G., & Chen, L. (2017). Effects of α-lipoic acid on growth performance, body composition, antioxidant status and lipid catabolism of juvenile Chinese mitten crab Eriocheir sinensis fed different lipid percentage. Aquaculture. https://doi.org/10.1016/j.aquaculture.2017.09.036 en
dc.identifier.doi https://doi.org/10.1016/j.aquaculture.2017.09.036 en
dc.identifier.issn 0044-8486
dc.identifier.uri http://hdl.handle.net/2328/37561
dc.language.iso en
dc.publisher Elsevier en
dc.rights © 2017 Elsevier en
dc.rights.holder Elsevier en
dc.rights.license CC-BY-NC-ND
dc.subject Eriocheir sinensis en
dc.subject α-Lipoic acid en
dc.subject Growth performance en
dc.subject Body composition en
dc.subject Antioxidant status en
dc.subject Lipid catabolism en
dc.title Effects of α-lipoic acid on growth performance, body composition, antioxidant status and lipid catabolism of juvenile Chinese mitten crab Eriocheir sinensis fed different lipid percentage en
dc.type Article en
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