Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series

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dc.contributor.author Bradshaw, R A
dc.contributor.author Mobley, W
dc.contributor.author Rush, Robert Archer
dc.date.accessioned 2017-07-24T00:44:58Z
dc.date.available 2017-07-24T00:44:58Z
dc.date.issued 2017-05-26
dc.description This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). en
dc.description.abstract Nerve growth factor (NGF) is a protein whose importance to research and its elucidation of fundamental mechanisms in cell and neurobiology far outstrips its basic physiological roles. It was the first of a broad class of cell regulators, largely acting through autocrine and paracrine interactions which will be described herein. It was of similar significance in establishing the identity and unique roles of neurotrophic factors in the development and maintenance of the peripheral and central nervous systems. Finally, it contributed to many advances in the elaboration of cell surface receptor mechanisms and intracellular cell signaling. As such, it can be considered to be a “molecular Rosetta Stone”. In this brief review, the highlights of these various studies are summarized, particularly as illustrated by their coverage in the 13 NGF international meetings that have been held since 1986. en
dc.identifier.citation Bradshaw, R.A.; Mobley, W.; Rush, R.A. Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. Int. J. Mol. Sci. 2017, 18, 1143. en
dc.identifier.doi https://doi.org/10.3390/ijms18061143 en
dc.identifier.issn 1422-0067
dc.identifier.uri http://hdl.handle.net/2328/37351
dc.language.iso en
dc.oaire.license.condition.license CC-BY
dc.publisher MDPI en
dc.rights © 2017 by the authors. en
dc.rights.holder the authors. en
dc.subject growth factors en
dc.subject neurotrophins en
dc.subject cell signaling en
dc.subject receptors en
dc.subject central nervous system en
dc.subject devleopment en
dc.title Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series en
dc.type Article en
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