Environmental occurrence of the Whipple's disease bacterium (Tropheryma whippelii).

dc.contributor.author Maiwald, Matthias
dc.contributor.author Schuhmacher, F
dc.contributor.author Ditton, H J
dc.contributor.author von Herbay, Axel
dc.date.accessioned 2007-08-21T04:37:49Z
dc.date.available 2007-08-21T04:37:49Z
dc.date.issued 1998-02
dc.description.abstract Whipple's disease is a systemic disorder in which a gram-positive rod-shaped bacterium is constantly present in infected tissues. After numerous unsuccessful attempts to culture this bacterium, it was eventually characterized by 16S rRNA gene analysis to be a member of the actinomycetes. The name Tropheryma whippelii was proposed. Until now, the bacterium has only been found in infected human tissues, but there is no evidence for human-to-human transmission. Here we report the detection of DNA specific for the Whipple's disease bacterium in 25 of 38 wastewater samples from five different sewage treatment plants in the area of Heidelberg, Germany. These findings provide the first evidence that T. whippelii occurs in the environment, within a polymicrobial community. This is in accordance with the phylogenetic relationship of this bacterium as well as with known epidemiological aspects of Whipple's disease. Our data argue for an environmental source for infection with the Whipple's disease bacterium. en
dc.identifier.citation Maiwald, M. Schuhmacher, F. Ditton, H.J. von Herbay, A. 1998 Environmental occurrence of the Whipple's disease bacterium (Tropheryma whippelii). Applied & Environmental Microbiology, 64(2), 760-762. en
dc.identifier.issn 0099-2240
dc.identifier.uri http://hdl.handle.net/2328/1698
dc.language.iso en
dc.publisher American Society for Microbiology en
dc.rights.license In Copyright
dc.subject Actinobacteria en
dc.subject Base Sequence en
dc.subject Molecular Sequence Data en
dc.subject Polymerase Chain Reaction en
dc.subject Whipple Disease en
dc.title Environmental occurrence of the Whipple's disease bacterium (Tropheryma whippelii). en
dc.type Article en
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