Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii)
Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii)
Date
2000
Authors
Maiwald, Matthias
von Herbay, Axel
Lepp, PW
Relman, David A
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
Whipple's disease is a systemic disorder associated with a cultivation-resistant, poorly characterized actinomycete, Tropheryma whippelii. We determined a nearly complete rRNA operon sequence of T. whippelii from specimens from 3 patients with Whipple's disease, as well as partial operon sequences from 43 patients. Variability was observed in the 16S-23S rRNA spacer sequences, leading to the description of five distinct sequence types. One specimen contained two spacer sequence types, raising the possibility of a double infection. Secondary structure models for the primary rRNA transcript and mature rRNAs revealed rare or unique features.
Description
This is the publisher’s copyrighted version of this article.
The original can be found at:
http://jb.asm.org/cgi/reprint/182/11/3292.pdf
Keywords
Actinomycetales,
Molecular Sequence Data,
Nucleic Acid Conformation,
Operon,
Phylogeny,
RNA, Ribosomal,
Whipple Disease
Citation
Maiwald, M. von Herbay, A. Lepp, PW. Relman, DA. 2000 Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii)., 'Journal of Bacteriology', Vol. 182, No. 11., 3292-7