Sleep apnea cardiovascular clinical trials - current status and steps forward: the International Collaboration of Sleep Apnea Cardiovascular Trialists
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Date
2013-02
Authors
Gottlieb, Daniel J
Craig, Sonya E
Lorenzi-Filho, Geraldo
Heeley, Emma
Redline, Susan
McEvoy, Ronald Douglas
Duran-Cantolla, Joaquin
Journal Title
Journal ISSN
Volume Title
Publisher
American Academy of Sleep Medicine
Rights
Rights Holder
© Copyright 2013 Associated Professional Sleep Societies, LLC
Abstract
Sleep apnea is a common chronic disease that is associated with coronary heart disease, stroke, heart failure and mortality, although the ability of sleep apnea treatment to reduce cardiovascular morbidity and mortality has not been demonstrated. In contrast to patients seeking treatment in sleep disorders centers, as many as half of individuals with moderate to severe sleep apnea in the general population do not report excessive sleepiness; however, if treatment of sleep apnea were shown to reduce cardiovascular disease risk, this would provide a strong rationale for treatment of sleep apnea even in the absence of daytime sleepiness. This article summarizes the status of clinical trials evaluating the potential cardiovascular benefits of sleep apnea treatment and discusses the challenges of conducting such trials, and introduces the International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT), a clinical research collaboration formed to foster cardiovascular sleep research.
Description
Keywords
Sleep apnea, Sleep study, Treatment, Cardiovascular morbidity, Sleep Research
Citation
Gottlieb, D.J., Craig, S.E., Lorenzi-Filho, G., Heeley, E., Redline, S., McEvoy, R.D. and Durán-Cantolla, J., 2013. Sleep apnea cardiovascular clinical trials— current status and steps forward: the International Collaboration of Sleep Apnea Cardiovascular Trialists. Sleep, 36(7), 975-980.