Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance
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Date
2018-12-05
Authors
Awadalla, Mona S
Fitzgerald, Jude T
Andrew, Nicholas H
Zhou, Tiger
Marshall, Henry
Qassim, Ayub
Hassall, Mark
Casson, Robert J
Graham, Stuart L
Healey, Paul R
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Rights
Copyright: © 2018 Awadalla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Rights Holder
Awadalla et al.
Abstract
Purpose
The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma.
Method
A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined.
Results
A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes.
Conclusion
The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.
Description
Copyright: © 2018 Awadalla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords
ganglion cell analysis (GCA), ganglion cell-inner plexiform layer (GCIPL) thickness, acquisition error
Citation
Awadalla MS, Fitzgerald J, Andrew NH, Zhou T, Marshall H, Qassim A, et al. (2018) Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance. PLoS ONE 13(12): e0206684. https://doi.org/ 10.1371/journal.pone.0206684