The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts

dc.contributor.author Williams, Keryn Anne
dc.contributor.author Kelly, T L
dc.contributor.author Lowe, Marie Therese
dc.contributor.author Coster, Douglas John
dc.date.accessioned 2014-09-30T06:11:28Z
dc.date.available 2014-09-30T06:11:28Z
dc.date.issued 2010 en
dc.description Author version made available in accordance with Publisher copyright policy. en
dc.description.abstract We investigated whether a rejection episode in one graft was associated with rejection in the other graft, in recipients with bilateral corneal transplants. In a prospectively maintained, national register of 14 865 followed corneal grafts, 1476 patients with bilateral penetrating corneal grafts were identified. Occurrence of rejection was a risk factor for graft failure (p < 0.0001). Logistic regression was used to calculate the adjusted odds ratio for rejection in one eye following rejection in the other eye. In the subset of 1118 patients with bilateral grafts but no history of previous grafts or rejections in either eye, the adjusted odds ratio for a rejection episode in the first eye following rejection in the second was 3.27 (95% confidence interval, CI 1.85, 5.79; p < 0.001). The adjusted odds ratio was 2.04 (95% CI 1.07, 3.91; p = 0.03) for rejection in the second eye following rejection in the first. The median time between the first rejection episode in one eye and the first rejection episode in the other eye was 15 months. Patients with bilateral corneal grafts who suffer a graft rejection episode in one eye are at significantly greater odds of suffering a rejection episode in the other corneal transplant. en
dc.identifier.citation Williams, K. A., Kelly, T.-L., Lowe, M. T., Coster, D. J. and on behalf of all contributors to the Australian Corneal Graft Registry (2010), The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts. American Journal of Transplantation, 10: 921–930. doi: 10.1111/j.1600-6143.2009.03002.x en
dc.identifier.doi https://doi.org/10.1111/j.1600-6143.2009.03002.x en
dc.identifier.issn 1600-6135
dc.identifier.rmid 2006017113
dc.identifier.uri http://hdl.handle.net/2328/32958
dc.language.iso en
dc.relation http://purl.org/au-research/grants/NHMRC/1002044 en
dc.relation.grantnumber NHMRC/1002044 en
dc.rights.license In Copyright
dc.subject.forgroup 1113 Ophthalmology and Optometry en
dc.title The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts en
dc.type Article en
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