The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts
Loading...
Date
2010
Authors
Williams, Keryn Anne
Kelly, T L
Lowe, Marie Therese
Coster, Douglas John
Journal Title
Journal ISSN
Volume Title
Publisher
Rights
Rights Holder
Abstract
We investigated whether a rejection episode in one
graft was associated with rejection in the other graft,
in recipients with bilateral corneal transplants. In a
prospectively maintained, national register of 14 865
followed corneal grafts, 1476 patients with bilateral
penetrating corneal grafts were identified. Occurrence
of rejection was a risk factor for graft failure (p <
0.0001). Logistic regression was used to calculate the
adjusted odds ratio for rejection in one eye following
rejection in the other eye. In the subset of 1118 patients
with bilateral grafts but no history of previous
grafts or rejections in either eye, the adjusted odds
ratio for a rejection episode in the first eye following
rejection in the second was 3.27 (95% confidence interval,
CI 1.85, 5.79; p < 0.001). The adjusted odds ratio
was 2.04 (95% CI 1.07, 3.91; p = 0.03) for rejection in
the second eye following rejection in the first. The median
time between the first rejection episode in one
eye and the first rejection episode in the other eye was
15 months. Patients with bilateral corneal grafts who
suffer a graft rejection episode in one eye are at significantly
greater odds of suffering a rejection episode in
the other corneal transplant.
Description
Author version made available in accordance with Publisher copyright policy.
Keywords
Citation
Williams, K. A., Kelly, T.-L., Lowe, M. T., Coster, D. J. and on behalf of all contributors to the Australian Corneal Graft Registry (2010), The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts. American Journal of Transplantation, 10: 921–930. doi: 10.1111/j.1600-6143.2009.03002.x