Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges
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Date
2016-05-10
Authors
Norris, Matthew D
Perkins, Michael Victor
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Rights
This journal is © The Royal Society of Chemistry 2016
Rights Holder
The Royal Society of Chemistry
Abstract
Marine sponges are widely known as a rich source of natural products, especially of polyketide origin, with a wealth of chemical diversity. Within this vast collection, peroxide and peroxide-derived secondary metabolites have attracted significant interest in the fields of natural product isolation and chemical synthesis for their structural distinction and promising in vitro antimicrobial and anticancer properties. In this review, peroxide and peroxide-derived polyketide metabolites isolated from marine sponges in the past 35 years are summarised. Efforts toward their synthesis are detailed with a focus on methods that utilise or attempt to elucidate the complex biosynthetic interrelationships of these compounds beyond enzymatic polyketide synthesis. Recent isolations, advances in synthetic methodology and theories of biogenesis are highlighted and critically evaluated.
Description
Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keywords
Marine sponges, polyketide, chemical diversity, metabolites
Citation
Norris, M. D., & Perkins, M. V. (2016). Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges. Natural product reports, 33(7), 861-880.