Anti-cholinergic load, health care utilization, and survival in people with advanced cancer: a pilot study

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dc.contributor.author Agar, Meera Ruth
dc.contributor.author To, Timothy H M
dc.contributor.author Plummer, John Lewis
dc.contributor.author Abernethy, Amy Pickar
dc.contributor.author Currow, David Christopher
dc.date.accessioned 2013-08-28T03:20:26Z
dc.date.available 2013-08-28T03:20:26Z
dc.date.issued 2010-07-02
dc.description.abstract Introduction: Anti-cholinergic medications have been associated with increased risks of cognitive impairment, premature mortality and increased risk of hospitalisation. Anti-cholinergic load associated with medication increases as death approaches in those with advanced cancer, yet little is known about associated adverse outcomes in this setting. Methods: A substudy of 112 participants in a randomised control trial who had cancer and an Australia modified Karnofsky Performance Scale (AKPS) score (AKPS) of 60 or above, explored survival and health service utilisation; with anti-cholinergic load calculated using the Clinician Rated Anti-cholinergic Scale (modified version) longitudinally to death. A standardised starting point for prospectively calculating survival was an AKPS of 60 or above. Results: Baseline entry to the sub-study was a mean 62 ± 81 days (median 37, range 1–588) days before death (survival), with mean of 4.8 (median 3, SD 4.18, range 1 – 24) study assessments in this time period. Participants spent 22% of time as an inpatient. There was no significant association between anti-cholinergic score and time spent as an inpatient (adjusted for survival time) (p = 0.94); or survival time. Discussion: No association between anti-cholinergic load and survival or time spent as an inpatient was seen. Future studies need to include cognitively impaired populations where the risks of symptomatic deterioration may be more substantial. en
dc.identifier.citation Agar, M.R., To, T.H.M., Plummer, J., Abernethy, A.P. and Currow, D.C., 2010. Anti-cholinergic load, health care utilization, and survival in people with advanced cancer: a pilot study. Journal of Palliative Medicine, 13(6), 745-752. en
dc.identifier.doi https://doi.org/10.1089/jpm.2009.0365 en
dc.identifier.issn 1096-6218
dc.identifier.uri http://hdl.handle.net/2328/27013
dc.language.iso en
dc.oaire.license.condition.license In Copyright
dc.publisher Mary Ann Liebert, Inc. en
dc.rights.holder (C) Mary Ann Liebert, Inc. 2010 en
dc.subject Palliative care
dc.title Anti-cholinergic load, health care utilization, and survival in people with advanced cancer: a pilot study en
dc.type Article en
local.contributor.authorOrcidLookup Currow, David Christopher: https://orcid.org/0000-0003-1988-1250 en_US
local.contributor.authorOrcidLookup To, Timothy H M: https://orcid.org/0000-0003-0025-6543
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