Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats

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dc.contributor.author Yazbeck, Roger
dc.contributor.author Lindsay, Ruth
dc.contributor.author Abbott, Catherine Anne
dc.contributor.author Benkendorff, Kirsten
dc.contributor.author Howarth, Gordon S
dc.date.accessioned 2018-06-12T02:04:26Z
dc.date.available 2018-06-12T02:04:26Z
dc.date.issued 2015-05-13
dc.date.updated 2018-04-26T08:34:31Z
dc.description Copyright © 2015 Roger Yazbeck et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.description.abstract Chemotherapy drugs, such as 5-fluorouracil (5FU), are the standard approach for cancer and are associated with several peripheral toxicities. We previously demonstrated that Muricidae marine molluscs exhibit chemopreventive properties. This study investigated the combined effect of muricid extract derived from Dicathais orbita, with 5FU, on intestinal toxicity in rats. Groups of rats were orally gavaged water, muricid extract, or sunflower oil, with or without 5FU (150 mg/kg). Metabolic data was collected daily and small intestinal brush border enzyme activity was measured by sucrose breath test (SBT). Blood was collected by cardiac puncture for whole blood analysis. Intestinal biopsies were taken for histopathology. Neutrophil activity was measured by myeloperoxidase activity. No additional toxicity effects were observed in rats receiving the combination of 5FU and muricid extract compared to 5FU alone, as indicated by SBT, histopathology, and myeloperoxidase activity. Intestinal integrity was protected from 5FU-induced damage in the sunflower oil vehicle group, compared to controls, as measured by SBT, villus height, and crypt depth. We concluded that combination of muricid extract and 5FU did not confer any additional intestinal toxicity, further supporting its potential as a chemopreventive food product. In this model system, sunflower oil partially protected against 5FU-induced intestinal toxicity.
dc.identifier.citation Roger Yazbeck, Ruth Lindsay, Catherine A. Abbott, Kirsten Benkendorff, and Gordon S. Howarth, “Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 170858, 9 pages, 2015. doi:10.1155/2015/170858
dc.identifier.doi https://doi.org/10.1155/2015/170858
dc.identifier.issn 1741-4288
dc.identifier.uri https://doi.org/10.1155/2015/170858
dc.identifier.uri http://hdl.handle.net/2328/38054
dc.language.iso en en
dc.publisher Hindawi en
dc.rights Copyright © 2015 Roger Yazbeck et al.
dc.rights.holder Roger Yazbeck et al.
dc.rights.license CC-BY
dc.subject Chemotherapy drugs
dc.subject 5-fluorouracil
dc.subject muricid extract
dc.subject Dicathais orbita
dc.subject intestinal toxicity
dc.title Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats en
dc.type Article en
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