Biocompatible anti-microbial coatings for urinary catheters

dc.contributor.authorThompson, Vaness C
dc.contributor.authorAdamson, Penny
dc.contributor.authorDilag, Jessirie
dc.contributor.authorUswatte Liyanage, Dhanushka Bandara Uswatte
dc.contributor.authorSrikantharajah, Kagithiri
dc.contributor.authorBlok, Andrew
dc.contributor.authorEllis, Amanda Vera
dc.contributor.authorGordon, David Llewellyn
dc.contributor.authorKoper, Ingo
dc.date.accessioned2017-04-11T00:10:28Z
dc.date.available2017-04-11T00:10:28Z
dc.date.issued2016-05-26
dc.descriptionOpen Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en
dc.description.abstractUsing a simple dip-coating mechanism, urinary catheters have been coated with poly(2-methacryloyloxyethyl)trimethylammonium chloride (pMTAC) using activator regenerated by electron transfer (ARGET)–atom transfer radical polymerization (ATRP). A polydopamine-2-bromoisobutyryl bromide (pDA-BiBBr) initiator was initially grafted to the catheter surface to initiate polymerization resulting in a pDA-g-pMTAC coating. The pDA-g-pMTAC-coated catheters showed a significant reduction in bacterial adhesion, with respect to uncoated silicone catheters, as determined by analyzing microbiological assays as well as scanning electron microscopy images. At the same time, no evidence for cytotoxicity was observed, rather, the coating promoted cell adhesion and proliferation of human cells. This makes the coating attractive for temporary as well as permanently implanted medical devices.en
dc.identifier.citationThompson, V. C., Adamson, P. J., Dilag, J., Liyanage, D. B. U. U., Srikantharajah, K., Blok, A., ... & Köper, I. (2016). Biocompatible anti-microbial coatings for urinary catheters. RSC Advances, 6(58), 53303-53309.en
dc.identifier.doihttps://doi.org/10.1039/c6ra07678een
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/2328/37141
dc.language.isoen
dc.oaire.license.condition.licenseCC-BY
dc.rightsThis journal is © The Royal Society of Chemistry 2016en
dc.rights.holderThe Royal Society of Chemistryen
dc.subjecturinary cathetersen
dc.subjectcathetersen
dc.subjectpoly(2- methacryloyloxyethyl)trimethylammonium chloride (pMTAC)en
dc.subjectpolymerizationen
dc.titleBiocompatible anti-microbial coatings for urinary cathetersen
dc.typeArticleen
local.contributor.authorOrcidLookupEllis, Amanda Vera: https://orcid.org/0000-0002-0053-5641en_US
local.contributor.authorOrcidLookupGordon, David Llewellyn: https://orcid.org/0000-0003-3276-9685en_US
local.contributor.authorOrcidLookupKoper, Ingo: https://orcid.org/0000-0002-5933-6495
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Thompson_Biocompatible_P2016.pdf
Size:
686.48 KB
Format:
Adobe Portable Document Format
Description:
Publisher version
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.84 KB
Format:
Item-specific license agreed upon to submission
Description: