Biocompatible anti-microbial coatings for urinary catheters

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Thompson, Vaness C
Adamson, Penny
Dilag, Jessirie
Uswatte Liyanage, Dhanushka Bandara Uswatte
Srikantharajah, Kagithiri
Blok, Andrew
Ellis, Amanda Vera
Gordon, David Llewellyn
Koper, Ingo
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This journal is © The Royal Society of Chemistry 2016
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The Royal Society of Chemistry
Using a simple dip-coating mechanism, urinary catheters have been coated with poly(2-methacryloyloxyethyl)trimethylammonium chloride (pMTAC) using activator regenerated by electron transfer (ARGET)–atom transfer radical polymerization (ATRP). A polydopamine-2-bromoisobutyryl bromide (pDA-BiBBr) initiator was initially grafted to the catheter surface to initiate polymerization resulting in a pDA-g-pMTAC coating. The pDA-g-pMTAC-coated catheters showed a significant reduction in bacterial adhesion, with respect to uncoated silicone catheters, as determined by analyzing microbiological assays as well as scanning electron microscopy images. At the same time, no evidence for cytotoxicity was observed, rather, the coating promoted cell adhesion and proliferation of human cells. This makes the coating attractive for temporary as well as permanently implanted medical devices.
Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
urinary catheters, catheters, poly(2- methacryloyloxyethyl)trimethylammonium chloride (pMTAC), polymerization
Thompson, V. C., Adamson, P. J., Dilag, J., Liyanage, D. B. U. U., Srikantharajah, K., Blok, A., ... & Köper, I. (2016). Biocompatible anti-microbial coatings for urinary catheters. RSC Advances, 6(58), 53303-53309.