Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Law, Matthew H; Bishop, D Timothy; Lee, Jeffrey E; Brossard, Myriam; Martin, Nicholas G; Moses, Eric K; Song, Fengju; Barrett, Jennifer H; Kumar, Rajiv; Easton, Douglas F; Pharoah, Paul D P; Swerdlow, Anthony J; Kypreou, Katerina P; Taylor, John C; Harland, Mark; Randerson-Moor, Juliette; Akslen, Lars A; Andresen, Per A; Avril, Marie-Francois; Azizi, Eesther; Scarra, Giovanna Bianch; Brown, Kevin; Debniak, Tadeusz; Duffy, David L; Elder, David E; Fang, Shenying; Friedman, Eeitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Elizabeth M; Goldstein, Alisa M; Gruis, Nelleke A; Hansson, Johan; Helsing, Per; Hocevar, Marko; Hoiom, Veronica; Ingvar, Christian; Kanetsky, Peter A; Chen, Wei V; Consortium, GenoMEL; Investigators, Essen-Heidelberg; Investigators, Q-MEGA and QTWIN; Investigators, AMFS; Study Group, ATHENS Melanoma; Landi, Maria Teresa; Lang, Julie; Lathrop, G Mark; Lubinski, Jan; Mackie, Rona M; Craig, Jamie E; Burdon, Kathryn Penelope; et. al.

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Date

2015

Authors

Law, Matthew H

Bishop, D Timothy

Lee, Jeffrey E

Brossard, Myriam

Martin, Nicholas G

Moses, Eric K

Song, Fengju

Barrett, Jennifer H

Kumar, Rajiv

Easton, Douglas F

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Publisher

Nature Publishing Group

Abstract

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.

Description

Author manuscript available from PMC http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557485/

Keywords

Genetics research, Melanoma, Genome-wide association studies

Citation

Law MH, Bishop DT, Lee JE, Brossard M, Martin NG, Moses EK, Song F, Barrett JH, Kumar R, Easton DF, Pharoah PD, Swerdlow AJ, Kypreou KP, Taylor JC, Harland M, Randerson-Moor J, Akslen LA, Andresen PA, Avril MF, Azizi E, Scarrà GB, Brown KM, Dȩbniak T, Duffy DL, Elder DE, Fang S, Friedman E, Galan P, Ghiorzo P, Gillanders EM, Goldstein AM, Gruis NA, Hansson J, Helsing P, Hočevar M, Höiom V, Ingvar C, Kanetsky PA, Chen WV; GenoMEL Consortium; Essen-Heidelberg Investigators; SDH Study Group; Q-MEGA and QTWIN Investigators; AMFS Investigators; ATHENS Melanoma Study Group, Landi MT, Lang J, Lathrop GM, Lubiński J, Mackie RM, Mann GJ, Molven A, Montgomery GW, Novaković S, Olsson H, Puig S, Puig-Butille JA, Qureshi AA, Radford-Smith GL, van der Stoep N, van Doorn R, Whiteman DC, Craig JE, Schadendorf D, Simms LA, Burdon KP, Nyholt DR, Pooley KA, Orr N, Stratigos AJ, Cust AE, Ward SV, Hayward NK, Han J, Schulze HJ, Dunning AM, Bishop JA, Demenais F, Amos CI, MacGregor S, Iles MM. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat Genet. 2015 Sep;47(9):987-95. doi: 10.1038/ng.3373.