Dipeptidyl Peptidase 10 (DPP10789): A Voltage Gated Potassium Channel Associated Protein Is Abnormally Expressed in Alzheimer’s and Other Neurodegenerative Diseases
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Date
2014
Authors
Chen, Tong
Gai, Wei Ping
Abbott, Catherine Anne
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing Corporation
Rights
Copyright © 2014 Tong Chen et al.
Rights Holder
Tong Chen et al.
Abstract
The neuropathological features associated with Alzheimer’s disease (AD) include the presence of extracellular amyloid-𝛽 peptidecontaining
plaques and intracellular tau positive neurofibrillary tangles and the loss of synapses and neurons in defined regions of
the brain. Dipeptidyl peptidase 10 (DPP10) is a protein that facilitates Kv4 channel surface expression and neuronal excitability. This
study aims to explore DPP10789 protein distribution in human brains and its contribution to the neurofibrillary pathology of AD
and other tauopathies. Immunohistochemical analysis revealed predominant neuronal staining of DPP10789 in control brains, and
the CA1 region of the hippocampus contained strong reactivity in the distal dendrites of the pyramidal cells. In AD brains, robust
DPP10789 reactivity was detected in neurofibrillary tangles and plaque-associated dystrophic neurites, most of which colocalized
with the doubly phosphorylated Ser-202/Thr-205 tau epitope. DPP10789 positive neurofibrillary tangles and plaque-associated
dystrophic neurites also appeared in other neurodegenerative diseases such as frontotemporal lobar degeneration, diffuse Lewy
body disease, and progressive supranuclear palsy. Occasional DPP10789 positive neurofibrillary tangles and neurites were seen in
some aged control brains.Western blot analysis showed both full length and truncatedDPP10789 fragments with the later increasing
significantly in AD brains compared to control brains. Our results suggest that DPP10789 is involved in the pathology of AD and
other neurodegenerative diseases.
Description
Copyright © 2014 Tong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords
Alzheimer's disease, Neurodegenerative diseases, Neuroscience
Citation
Chen T, Gai WP, Abbott CA. Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases. BioMed Research International. 2014;2014:209398.