Endothelial Progenitor Cells Enhance Islet Engraftment, Influence b-Cell Function, and Modulate Islet Connexin 36 Expression

dc.contributor.author Penko, D
dc.contributor.author Rojas-Canales
dc.contributor.author Mohanasundaram, Daisy
dc.contributor.author Peiris, Heshan
dc.contributor.author Sun, Wai Y.
dc.contributor.author Drogemuller, Chris J
dc.contributor.author Keating, Damien John
dc.contributor.author Coates, P Toby
dc.contributor.author Bonder, Claudine
dc.contributor.author Jessup, Claire Frances
dc.date.accessioned 2015-02-09T23:13:58Z
dc.date.available 2015-02-09T23:13:58Z
dc.date.issued 2015
dc.description This article has been made available by the publisher under a Creative Commons Attribution Non-Commercial (CC BY NC) license. https://www.cognizantcommunication.com/general-subscription-policies/open-access-policy Accessed 10/2/15 en
dc.description.abstract The success of pancreatic islet transplantation is limited by delayed engraftment and suboptimal function in the longer term. Endothelial progenitor cells (EPCs) represent a potential cellular therapy that may improve the engraftment of transplanted pancreatic islets. In addition, EPCs may directly affect the function of pancreatic β-cells. The objective of this study was to examine the ability of EPCs to enhance pancreatic islet transplantation in a murine syngeneic marginal mass transplant model and to examine the mechanisms through which this occurs. We found that cotransplanted EPCs improved the cure rate and initial glycemic control of transplanted islets. Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the β-cell surface molecule connexin 36 and affect glucose-stimulated insulin release in vitro. In conclusion, EPCs are a promising candidate for improving outcomes in islet transplantation, and their mechanisms of action warrant further study. en
dc.identifier.citation Penko D, Rojas-Canales D, Mohanasundaram D, Peiris HS, Sun WY, Drogemuller CJ, Keating DJ, Coates PT, Bonder CS, Jessup CF. Endothelial Progenitor Cells Enhance Islet Engraftment, Influence β-Cell Function, and Modulate Islet Connexin 36 Expression. Cell Transplant. 2015;24(1):37-48. en
dc.identifier.doi https://doi.org/10.3727/096368913X673423 en
dc.identifier.issn 0963-6897
dc.identifier.uri http://hdl.handle.net/2328/35197
dc.language.iso en
dc.oaire.license.condition.license CC-BY-NC
dc.publisher Cognizant Communication Coporation, LLC en
dc.relation http://purl.org/au-research/grants/nhmrc/1008816 en
dc.relation.grantnumber NHMRC/1008816 en
dc.rights Copyright © 2015 Cognizant Communication Corporation en
dc.rights.holder Cognizant Communication Corporation en
dc.title Endothelial Progenitor Cells Enhance Islet Engraftment, Influence b-Cell Function, and Modulate Islet Connexin 36 Expression en
dc.type Article en
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