Endothelial Progenitor Cells Enhance Islet Engraftment, Influence b-Cell Function, and Modulate Islet Connexin 36 Expression

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dc.contributor.authorPenko, D
dc.contributor.authorRojas-Canales
dc.contributor.authorMohanasundaram, Daisy
dc.contributor.authorPeiris, Heshan
dc.contributor.authorSun, Wai Y.
dc.contributor.authorDrogemuller, Chris J
dc.contributor.authorKeating, Damien John
dc.contributor.authorCoates, P Toby
dc.contributor.authorBonder, Claudine
dc.contributor.authorJessup, Claire Frances
dc.date.accessioned2015-02-09T23:13:58Z
dc.date.available2015-02-09T23:13:58Z
dc.date.issued2015
dc.descriptionThis article has been made available by the publisher under a Creative Commons Attribution Non-Commercial (CC BY NC) license. https://www.cognizantcommunication.com/general-subscription-policies/open-access-policy Accessed 10/2/15en
dc.description.abstractThe success of pancreatic islet transplantation is limited by delayed engraftment and suboptimal function in the longer term. Endothelial progenitor cells (EPCs) represent a potential cellular therapy that may improve the engraftment of transplanted pancreatic islets. In addition, EPCs may directly affect the function of pancreatic β-cells. The objective of this study was to examine the ability of EPCs to enhance pancreatic islet transplantation in a murine syngeneic marginal mass transplant model and to examine the mechanisms through which this occurs. We found that cotransplanted EPCs improved the cure rate and initial glycemic control of transplanted islets. Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the β-cell surface molecule connexin 36 and affect glucose-stimulated insulin release in vitro. In conclusion, EPCs are a promising candidate for improving outcomes in islet transplantation, and their mechanisms of action warrant further study.en
dc.identifier.citationPenko D, Rojas-Canales D, Mohanasundaram D, Peiris HS, Sun WY, Drogemuller CJ, Keating DJ, Coates PT, Bonder CS, Jessup CF. Endothelial Progenitor Cells Enhance Islet Engraftment, Influence β-Cell Function, and Modulate Islet Connexin 36 Expression. Cell Transplant. 2015;24(1):37-48.en
dc.identifier.doihttps://doi.org/10.3727/096368913X673423en
dc.identifier.issn0963-6897
dc.identifier.urihttp://hdl.handle.net/2328/35197
dc.language.isoen
dc.oaire.license.condition.licenseCC-BY-NC
dc.publisherCognizant Communication Coporation, LLCen
dc.relationhttp://purl.org/au-research/grants/nhmrc/1008816en
dc.relation.grantnumberNHMRC/1008816en
dc.rightsCopyright © 2015 Cognizant Communication Corporationen
dc.rights.holderCognizant Communication Corporationen
dc.titleEndothelial Progenitor Cells Enhance Islet Engraftment, Influence b-Cell Function, and Modulate Islet Connexin 36 Expressionen
dc.typeArticleen
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