Endothelial Progenitor Cells Enhance Islet Engraftment, Influence b-Cell Function, and Modulate Islet Connexin 36 Expression
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Date
2015
Authors
Penko, D
Rojas-Canales
Mohanasundaram, Daisy
Peiris, Heshan
Sun, Wai Y.
Drogemuller, Chris J
Keating, Damien John
Coates, P Toby
Bonder, Claudine
Jessup, Claire Frances
Journal Title
Journal ISSN
Volume Title
Publisher
Cognizant Communication Coporation, LLC
Rights
Copyright © 2015 Cognizant Communication Corporation
Rights Holder
Cognizant Communication Corporation
Abstract
The success of pancreatic islet transplantation is limited by delayed engraftment and suboptimal function in the longer term. Endothelial progenitor cells (EPCs) represent a potential cellular therapy that may improve the engraftment of transplanted pancreatic islets. In addition, EPCs may directly affect the function of pancreatic β-cells. The objective of this study was to examine the ability of EPCs to enhance pancreatic islet transplantation in a murine syngeneic marginal mass transplant model and to examine the mechanisms through which this occurs. We found that cotransplanted EPCs improved the cure rate and initial glycemic control of transplanted islets. Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the β-cell surface molecule connexin 36 and affect glucose-stimulated insulin release in vitro. In conclusion, EPCs are a promising candidate for improving outcomes in islet transplantation, and their mechanisms of action warrant further study.
Description
This article has been made available by the publisher under a Creative Commons Attribution Non-Commercial (CC BY NC) license. https://www.cognizantcommunication.com/general-subscription-policies/open-access-policy Accessed 10/2/15
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Citation
Penko D, Rojas-Canales D, Mohanasundaram D, Peiris HS, Sun WY, Drogemuller CJ, Keating DJ, Coates PT, Bonder CS, Jessup CF. Endothelial Progenitor Cells Enhance Islet Engraftment, Influence β-Cell Function, and Modulate Islet Connexin 36 Expression. Cell Transplant. 2015;24(1):37-48.