Anxiety can significantly explain bolus perception in the context of hypotensive esophageal motility: Results of a large multicenter study in asymptomatic individuals

dc.contributor.author Cisternas, Daniel
dc.contributor.author Scheerens, C
dc.contributor.author Omari, Taher
dc.contributor.author Monrroy, H
dc.contributor.author Hani, A
dc.contributor.author Leguizamo, A
dc.contributor.author Bilder, C
dc.contributor.author Ditaranto, A
dc.contributor.author Ruiz de Leon, A
dc.contributor.author Perez de la Serna, J
dc.contributor.author Valdovinos, M A
dc.contributor.author Coello, R
dc.contributor.author Abrahao, L
dc.contributor.author Remes-Troche, J
dc.contributor.author Meixueiro, A
dc.contributor.author Zavala, M A
dc.contributor.author Marin, I
dc.contributor.author Serra, J
dc.date.accessioned 2018-04-03T23:22:24Z
dc.date.available 2018-04-03T23:22:24Z
dc.date.issued 2017-05-07
dc.description This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving'. © 2017 John Wiley & Sons, Inc. All rights reserved. This author accepted manuscript is made available following 12 month embargo from date of publication (May 2017) in accordance with the publisher’s archiving policy en
dc.description.abstract Background Previous studies have not been able to correlate manometry findings with bolus perception. The aim of this study was to evaluate correlation of different variables, including traditional manometric variables (at diagnostic and extreme thresholds), esophageal shortening, bolus transit, automated impedance manometry (AIM) metrics and mood with bolus passage perception in a large cohort of asymptomatic individuals. Methods High resolution manometry (HRM) was performed in healthy individuals from nine centers. Perception was evaluated using a 5‐point Likert scale. Anxiety was evaluated using Hospitalized Anxiety and Depression scale (HAD). Subgroup analysis was also performed classifying studies into normal, hypotensive, vigorous, and obstructive patterns. Key Results One hundred fifteen studies were analyzed (69 using HRM and 46 using high resolution impedance manometry (HRIM); 3.5% swallows in 9.6% of volunteers were perceived. There was no correlation of any of the traditional HRM variables, esophageal shortening, AIM metrics nor bolus transit with perception scores. There was no HRM variable showing difference in perception when comparing normal vs extreme values (percentile 1 or 99). Anxiety but not depression was correlated with perception. Among hypotensive pattern, anxiety was a strong predictor of variance in perception (R2 up to .70). Conclusion and Inferences Bolus perception is less common than abnormal motility among healthy individuals. Neither esophageal motor function nor bolus dynamics evaluated with several techniques seems to explain differences in bolus perception. Different mechanisms seem to be relevant in different manometric patterns. Anxiety is a significant predictor of bolus perception in the context of hypotensive motility. en
dc.identifier.citation Cisternas, D., Scheerens, C., Omari, T., Monrroy, H., Hani, A., Leguizamo, A., … Serra, J. (2017). Anxiety can significantly explain bolus perception in the context of hypotensive esophageal motility: Results of a large multicenter study in asymptomatic individuals. Neurogastroenterology & Motility, 29(9), e13088. https://doi.org/10.1111/nmo.13088 en
dc.identifier.doi https://doi.org/10.1111/nmo.13088 en
dc.identifier.issn 1365-2982
dc.identifier.uri http://hdl.handle.net/2328/37840
dc.language.iso en
dc.publisher Wiley en
dc.rights © 2017 John Wiley & Sons, Inc. en
dc.rights.holder John Wiley & Sons, Inc. en
dc.rights.license In Copyright
dc.subject bolus perception en
dc.subject esophageal shortening, en
dc.subject Manometry en
dc.subject bolus transit en
dc.subject automated impedance manometry (AIM) en
dc.subject High resolution manometry (HRM) en
dc.title Anxiety can significantly explain bolus perception in the context of hypotensive esophageal motility: Results of a large multicenter study in asymptomatic individuals en
dc.type Article en
local.contributor.authorOrcidLookup Omari, Taher: https://orcid.org/0000-0001-5108-7378 en_US
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