Nocturnal Hypoxemia and Severe Obstructive Sleep Apnea are Associated with Incident Type 2 Diabetes in a Population Cohort of Men

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dc.contributor.author Appleton, Sarah L
dc.contributor.author Vakulin, Andrew
dc.contributor.author McEvoy, Ronald Douglas
dc.contributor.author Wittert, Gary Allen
dc.contributor.author Martin, Sean A
dc.contributor.author Grant, Janet F
dc.contributor.author Taylor, Anne
dc.contributor.author Antic, Nicholas Alexander
dc.contributor.author Catcheside, Peter G
dc.contributor.author Adams, Robert J
dc.date.accessioned 2016-02-23T23:33:46Z
dc.date.available 2016-02-23T23:33:46Z
dc.date.issued 2015
dc.description Freely available online at PubMed Central <http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25766697/> en
dc.description.abstract Study Objectives Studies examining the longitudinal association of untreated obstructive sleep apnea (OSA) with diabetes in population samples are limited. This study therefore examined the relationship between previously undiagnosed OSA with incident type 2 diabetes in community-dwelling men aged ≥ 40 y. Methods The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study is a longitudinal population-based cohort in Adelaide, South Australia. Clinic assessments at baseline and follow-up identified diabetes (self-reported doctor diagnosed, fasting plasma glucose ≥ 7.0 mmol/L, glycated hemoglobin ≥ 6.5% or diabetes medication use) and included anthropometry. At cohort follow-up (2010–2012), n = 837 underwent full in-home unattended polysomnography (PSG, Embletta X100, Broomfield, CO). Results Of 736 men free of diabetes at baseline, incident diabetes occurred in 66 (9.0%) over a mean follow-up time of 56 mo (standard deviation = 5, range: 48–74 mo). Incident diabetes was associated with current oxygen desaturation index (3%) ≥ 16 events/h (odds ratio [OR]: 1.85 [1.06–3.21]), and severe OSA [OR: 2.6 (1.1–6.1)], in adjusted models including age, percentage total body fat, and weight gain (> 5 cm waist circumference). An age-adjusted association of incident diabetes with percentage of total sleep time with oxygen saturation < 90% did not persist after adjustment for percentage of body fat. No modification of these relationships by excessive daytime sleepiness was observed. Conclusions Severe undiagnosed OSA and nocturnal hypoxemia were independently associated with the development of diabetes. A reduction in the burden of undiagnosed OSA and undiagnosed diabetes is likely to occur if patients presenting with one disorder are assessed for the other. en
dc.identifier.citation Appleton, S.L., Vakulin, A., McEvoy, R.D., Wittert, G.A., martin, S., Grant, J.F., et al. (2015). Nocturnal Hypoxemia and Severe Obstructive Sleep Apnea are Associated with Incident Type 2 Diabetes in a Population Cohort of Men. Journal of Clinical Sleep Medicine, 11(6) pp. 609-614. en
dc.identifier.doi https://doi.org/10.5664/jcsm.4768 en
dc.identifier.issn 1550-9389
dc.identifier.uri http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25766697/
dc.identifier.uri http://hdl.handle.net/2328/35977
dc.language.iso en en
dc.publisher American Academy of Sleep Medicine en
dc.relation http://purl.org/au-research/grants/NHMRC/627227 en
dc.relation.grantnumber NHMRC/627227 en
dc.rights Copyright © 2015 Associated Professional Sleep Societies, LLC. Published by American Academy of Sleep Medicine. en
dc.rights.holder Associated Professional Sleep Societies, LLC en
dc.title Nocturnal Hypoxemia and Severe Obstructive Sleep Apnea are Associated with Incident Type 2 Diabetes in a Population Cohort of Men en
dc.type Article en
local.contributor.authorOrcidLookup McEvoy, Ronald Douglas: https://orcid.org/0000-0002-5759-0094 en_US
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