Smart surface-enhanced Raman scattering traceable drug delivery systems

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Liu, Lei
Tang, Youhong
Dai, Sheng
Kleitz, Freddy
Qiao, Shi Zhang
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Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2016
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The Royal Society of Chemistry
A novel smart nanoparticle-based system has been developed for tracking intracellular drug delivery through surface-enhanced Raman scattering (SERS). This new drug delivery system (DDS) shows targeted cytotoxicity towards cancer cells via pH-cleavable covalent carboxylic hydrazone links and the SERS tracing capability based on gold@silica nanocarriers. Doxorubicin, as a model anticancer drug, was employed to compare SERS with conventional fluorescence tracing approaches. It is evident that SERS demonstrates higher sensitivity and resolution, revealing intracellular details, as the strengths of the original Raman signals can be amplified by SERS. Importantly, non-destructive SERS will provide the designed DDS with great autonomy and potential to study the dynamic procedures of non-fluorescent drug delivery into living cells.
Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
nanoparticle, surface-enhanced Raman scattering, drug delivery system, cancer cells
Liu, L., Tang, Y., Dai, S., Kleitz, F., & Qiao, S. Z. (2016). Smart surface-enhanced Raman scattering traceable drug delivery systems. Nanoscale, 8(25), 12803-12811.