Smart surface-enhanced Raman scattering traceable drug delivery systems
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Date
2016-05-30
Authors
Liu, Lei
Tang, Youhong
Dai, Sheng
Kleitz, Freddy
Qiao, Shi Zhang
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Rights
This journal is © The Royal Society of Chemistry 2016
Rights Holder
The Royal Society of Chemistry
Abstract
A novel smart nanoparticle-based system has been developed for tracking intracellular drug delivery through surface-enhanced Raman scattering (SERS). This new drug delivery system (DDS) shows targeted cytotoxicity towards cancer cells via pH-cleavable covalent carboxylic hydrazone links and the SERS tracing capability based on gold@silica nanocarriers. Doxorubicin, as a model anticancer drug, was employed to compare SERS with conventional fluorescence tracing approaches. It is evident that SERS demonstrates higher sensitivity and resolution, revealing intracellular details, as the strengths of the original Raman signals can be amplified by SERS. Importantly, non-destructive SERS will provide the designed DDS with great autonomy and potential to study the dynamic procedures of non-fluorescent drug delivery into living cells.
Description
Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keywords
nanoparticle, surface-enhanced Raman scattering, drug delivery system, cancer cells
Citation
Liu, L., Tang, Y., Dai, S., Kleitz, F., & Qiao, S. Z. (2016). Smart surface-enhanced Raman scattering traceable drug delivery systems. Nanoscale, 8(25), 12803-12811.