Post-stroke sleep-disordered breathing - pathophysiology and therapy options

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dc.contributor.author Stevens, David
dc.contributor.author Martins, Rodrigo Tomazini
dc.contributor.author Mukherjee, Sutapa
dc.contributor.author Vakulin, Andrew
dc.date.accessioned 2018-09-14T03:13:56Z
dc.date.available 2018-09-14T03:13:56Z
dc.date.issued 2018-02-26
dc.description Note: This article was submitted to Otorhinolaryngology - Head and Neck Surgery, a section of the journal Frontiers in Surgery. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en_US
dc.description.abstract Sleep-disordered breathing (SDB), encompassing both obstructive and central sleep apnea, is prevalent in at least 50% of stroke patients. Small studies have shown vast improvements in post-stroke functional recovery outcomes after the treatment of SDB by continuous positive airway pressure. However, compliance to this therapy is very poor in this complex patient group. There are alternative therapy options for SDB that may be more amenable for use in at least some post-stroke patients, including mandibular advancement, supine avoidance, and oxygen therapy. There are few studies, however, that demonstrate efficacy and compliance with these alternative therapies currently. Furthermore, novel SDB-phenotyping approaches may help to provide important clinical information to direct therapy selection in individual patients. Prior to realizing individualized therapy, we need a better understanding of the pathophysiology of SDB in post-stroke patients, including the role of inherent phenotypic traits, as well as the contribution of stroke size and location. This review summarizes the available literature on SDB pathophysiology and treatment in post-stroke patients, identifies gaps in the literature, and sets out areas for further research. en_US
dc.identifier.citation Stevens, D., Martins, R.T., Mukherjee, S. and Vakulin, A., (2018). Post-Stroke Sleep-Disordered Breathing — Pathophysiology and Therapy Options. Front. Surg. 5:9. doi: 10.3389/fsurg.2018.00009. en_US
dc.identifier.doi https://doi.org/10.3389/fsurg.2018.00009 en_US
dc.identifier.issn 2296-875X
dc.identifier.uri http://hdl.handle.net/2328/38289
dc.language.iso en en_US
dc.oaire.license.condition.license CC-BY
dc.publisher Frontiers Media en_US
dc.rights Copyright © 2018 Stevens, Martins, Mukherjee and Vakulin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en_US
dc.rights.holder Copyright © 2018 Stevens, Martins, Mukherjee and Vakulin. en_US
dc.subject stroke en_US
dc.subject sleep apnea en_US
dc.subject hypopnea en_US
dc.subject treatment en_US
dc.subject phenotyping en_US
dc.title Post-stroke sleep-disordered breathing - pathophysiology and therapy options en_US
dc.type Article en
local.contributor.authorOrcidLookup Stevens, David: https://orcid.org/0000-0002-8412-2202 en_US
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