Predicting the Activation States of the Muscles Governing Upper Esophageal Sphincter Relaxation and Opening

dc.contributor.authorOmari, Taher
dc.contributor.authorJones, Corinne A
dc.contributor.authorHammer, Marilyn J
dc.contributor.authorCock, Charles
dc.contributor.authorDinning, Philip
dc.contributor.authorWiklendt, Lukasz
dc.contributor.authorCosta, Marcello
dc.contributor.authorMcCulloch, Timothy M
dc.date.accessioned2017-03-27T04:35:31Z
dc.date.available2017-03-27T04:35:31Z
dc.date.issued2016-03-15
dc.descriptionCopyright © 2016 the American Physiological Societyen
dc.description.abstractThe swallowing muscles that influence upper esophageal sphincter (UES) opening are centrally controlled and modulated by sensory information. Activation and deactivation of neural inputs to these muscles, including the intrinsic cricopharyngeus (CP) and extrinsic submental (SM) muscles, results in their mechanical activation or deactivation, which changes the diameter of the lumen, alters the intraluminal pressure, and ultimately reduces or promotes flow of content. By measuring the changes in diameter, using intraluminal impedance, and the concurrent changes in intraluminal pressure, it is possible to determine when the muscles are passively or actively relaxing or contracting. From these “mechanical states” of the muscle, the neural inputs driving the specific motor behaviors of the UES can be inferred. In this study we compared predictions of UES mechanical states directly with the activity measured by electromyography (EMG). In eight subjects, pharyngeal pressure and impedance were recorded in parallel with CP- and SM-EMG activity. UES pressure and impedance swallow profiles correlated with the CP-EMG and SM-EMG recordings, respectively. Eight UES muscle states were determined by using the gradient of pressure and impedance with respect to time. Guided by the level and gradient change of EMG activity, mechanical states successfully predicted the activity of the CP muscle and SM muscle independently. Mechanical state predictions revealed patterns consistent with the known neural inputs activating the different muscles during swallowing. Derivation of “activation state” maps may allow better physiological and pathophysiological interpretations of UES function.en
dc.identifier.citationOmari TI, Jones CA Ms, Hammer MJ, Cock C, Dinning PG, Wiklendt L, Costa MC, McCulloch TM. Predicting the Activation States of the Muscles Governing Upper Esophageal Sphincter Relaxation and Opening. Am J Physiol Gastrointest Liver Physiol. 2016 Mar 15;310(6):G359-66.en
dc.identifier.doihttps://doi.org/10.1152/ajpgi.00388.2015en
dc.identifier.issn0193-1857
dc.identifier.urihttp://hdl.handle.net/2328/37006
dc.language.isoen
dc.oaire.license.condition.licenseIn Copyright
dc.publisherAmerican Physiological Societyen
dc.rightsCopyright © 2016 the American Physiological Societyen
dc.rights.holderAmerican Physiological Societyen
dc.subjectdeglutitionen
dc.subjectdysphagiaen
dc.subjectpressureen
dc.subjectimpedanceen
dc.subjectdiameteren
dc.subjectelectromyographyen
dc.subjectneural pathwaysen
dc.subjectupper esophageal sphincteren
dc.subjectcricopharyngeus muscleen
dc.subjectsubmental musclesen
dc.titlePredicting the Activation States of the Muscles Governing Upper Esophageal Sphincter Relaxation and Openingen
dc.typeArticleen
local.contributor.authorOrcidLookupOmari, Taher: https://orcid.org/0000-0001-5108-7378en_US
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