0601 - Biochemistry and Cell Biology
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This collection contains Flinders' research in Biochemistry and Cell Biology, as reported for ERA 2012.
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Item DNA binding-independent transcriptional activation of the vascular endothelial growth factor gene (VEGF) by the Myb oncoprotein(2006) Keough, Rebecca; Coles, Leeanne; Gonda, Thomas; Lutwyche, Jodi; Hunter, JulieItem Cloning and structure analysis of hydrogenase gene from Chlamydomonas reinhardtii SE(2005) L.H., Zhang; Jin, Meifang; HY, Zhang; Wang, Y-J; Zhang, WeiItem Dengue virus (DV) replication in monocyte-derived macrophages is not affected by tumor necrosis factor alpha (TNF-A) and DV infection induces altered responsiveness to TNF-A stimulation(2007) Li, Peng; Carr, Jill; Wati, Satiya; Burrell, ChristopherItem Dengue Virus Infection Induces Upregulation of GRP78, Which Acts To Chaperone Viral Antigen Production(2009) Soo, M-L; Li, Peng; Paton, A; Burrell, Christopher; Zilm, P; Carr, Jill; Beard, Michael; Wati, SItem Human immunodeficiency virus 1 (HIV-1) virion infectivity factor (Vif) is part of reverse transcription complexes and acts as an accessory factor for reverse transcription(2008) Carr, Jill; Coolen, Carl; Davis, Adam; Burrell, Christopher; Li, PengItem Vif-deficient HIV reverse transcription complexes (RTCs) are subject to APOBEC3G-mediated structural changes and mutation of RTC associated reverse transcription products(2006) Davis, Adam; Carr, Jill; Coolen, Carl; Cheney, Kelly; Burrell, Christopher; Li, PengItem Bi-directional interactions of prostate cancer cells and bone marrow endothelial cells in three-dimensional culture(2005) Barrett, Jeffery; Jilling, Tamas; Kaul, Karen; Mangold, KathyItem Prostate cancer cells regulate growth and differentiation of bone marrow endothelial cells through TGF{beta} and its receptor, TGF{beta}RII(2006) Rovedo, Mark; Mangold, Kathy; Kaul, Karen; Barrett, Jeffery; Tajuddin, Aamair; Jilling, Tamas; Macoska, Jill; MacDonald, JamesItem Methyl mercury influences growth-related signaling in MCF-7 breast cancer cells(2005) Yang, Yi; Seegal, Richard F; Sukocheva, Olga Anatolyevna; Gierthy, John FItem p160 Myb-binding protein interacts with Prep1 and inhibits its transcriptional activity(2007) Díaz, Víctor; Mori, Silvia; Longobardi, Elena; Bachi, Angela; Menendez, Guillermo; Ferrai, Carmelo; Blasi, Francesco; Keough, RebeccaItem The SMN interactome includes Myb-binding protein 1a(2010) Fuller, Heidi; Thanh, Le; Asperger, Arndt; Morris, Glenn; Man, Nguyen; Keough, Rebecca; Gonda, Thomas; Lam, LeItem Increasing cycles of intermittent ischemia can effectively maintain liver function during the acute phase of ischemia reperfusion injury by promotion of bile flow and reduction in bile salt toxicity(2009) Peters, Joseph E; Nieuwenhuijs, Vincent; Porte, Robert Jack; Padbury, Robert Thomas; Barritt, Gregory John; Morphett, ArthurItem Ribosomal stress induces processing of Mybbp1a and its translocation from the nucleolus to the nucleoplasm(2008) Yamauchi, Tomohiro; Keough, Rebecca; Gonda, Thomas; Ishii, shunsukeItem Estrogen and progesterone interactive effects in postconfluent MCF-7 cell culture.(2009) Sukocheva, Olga Anatolyevna; Gierthy, John F; Yang, YiItem l-Proline induces differentiation of ES cells: a novel role for an amino acid in the regulation of pluripotent cells in culture(2010) Washington, Jennifer; lonic, Ana; bettess, Michael; Hamra, Nancy; semendric, ljiljana; Lake, Julie-Anne; morris, michael; Rathjen, Peter; Keough, Rebecca Anne; Tan, BS; Rathjen, J; felquer, fernandoItem Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation(2010) To, Sarah; Rathjen, Peter; Keough, Rebecca; Rodda, StephenCRTR-1 is a member of the CP2 family of transcription factors. Unlike other members of the family which are widely expressed, CRTR-1 expression shows specific spatio-temporal regulation. Gene targeting demonstrates that CRTR-1 plays a central role in the maturation and function of the salivary glands and the kidney. CRTR-1 has also recently been identified as a component of the complex transcriptional network that maintains pluripotency in embryonic stem (ES) cells. CRTR-1 was previously shown to be a repressor of transcription. We examine the activity of CRTR-1 in ES and other cells and show that CRTR-1 is generally an activator of transcription and that it modulates the activity of other family members, CP2, NF2d9 and altNF2d9, in a cell specific manner. We also demonstrate that CRTR-1 activity is regulated by sumoylation at a single major site, residue K30. These findings imply that functional redundancy with other family members may mask important roles for CRTR-1 in other tissues, including the blastocyst stage embryo and embryonic stem cells.Item Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells.(2010) Aromataris, Edoardo; Rychkov, Grigori Y; Castro, Joel; Roberts, Michael L; To, Minh-Son; Barritt, Gregory JohnItem If bystander effects for apoptosis occur in spleen after low dose irradiation in vivo then the magnitude of the effect falls within the range of normal homeostatic apoptosis(2010) Lawrence, Mark D; Blyth, Benjamin John; Ormsby, Rebecca Jane; Bezak, Eva; Staudacher, Alexander; Sykes, Pamela JoyItem The Homeobox Transcription Factor Barx2 Regulates Plasticity of Young Primary Myofibers(2010) Barro, Marietta; Hulin, Julie-Ann; Walcott, Elizabeth C; Delgado, J; Makarenkova, Helen; Meech, Robyn; Gomez, Mariana; Woolley, ChristopherAdult mammalian muscle retains incredible plasticity. Muscle growth and repair involves the activation of undifferentiated myogenic precursors called satellite cells. In some circumstances, it has been proposed that existing myofibers may also cleave and produce a pool of proliferative cells that can re-differentiate into new fibers. Such myofiber dedifferentiation has been observed in the salamander blastema where it may occur in parallel with satellite cell activation. Moreover, ectopic expression of the homeodomain transcription factor Msx1 in differentiated C2C12 myotubes has been shown to induce their dedifferentiation. While it remains unclear whether dedifferentiation and redifferentiaton occurs endogenously in mammalian muscle, there is considerable interest in induced dedifferentiation as a possible regenerative tool.Item Intermittent ischaemia maintains function after ischaemia reperfusion in steatotic livers(2010) Callahan, Tom; Teo, E H; De Bruijn, Menno; Padbury, Robert Thomas; Barritt, Gregory John; Van Baal, Mark C P M; Schiesser, Marc; Nieuwenhuijs, Vincent; Steenks, M
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