0604 - Genetics
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This collection contains Flinders' staff research in Genetics, reportable as part of Excellence in Research for Australia (ERA), from 2001-
Items are added automatically from Flinders University Research Services Office.
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Item Social complexity in bees is not sufficient to explain lack of reversions to solitary living over long time scales(2007) Chenoweth, Luke; Smith, Jaclyn Amanda; Cooper, Steven J B; Schwarz, Michael Philip; Tierney, Simon MItem Prevalence of CYP1B1 mutations in Australian patients with primary congenital glaucoma(2007) Elder, James E; Casey, T; Mackey, David A; Craig, Jamie E; MacKinnon, Jane R; Hewitt, Alex W; Dimasi, David Paul; Pater, John Brian; Straga, TaniaItem Nance-Horan syndrome protein, NHS, associates with epithelial cell junctions(2006) Sharma, Shiwani; Ang, Sharyn; Shaw, Marie A; Mackey, David A; Gecz, Jozef; McAvoy, J; Craig, Jamie EItem Know thy fly(2007) Chataway, Timothy Kennion; O'Keefe, Louise; Richards, Robert; Smibert, Peter; Saint, Robert; Colella, AlexItem Risk management: reducing risk through confinement of transgenic fish(CAB International, 2007) Mair, Graham Charles; Nam, Y K; Solar, I.IItem Lack of association of p53 polymorphisms and haplotypes in high and normal tension open angle glaucoma(2005) Dimasi, David Paul; Hewitt, Alex W; Green, Catherine M; Mackey, David A; Craig, Jamie EItem Cytotoxicity and genotoxicity of ultrafine crystalline SiO2 particulate in cultured human lymphoblastoid cells(2007) Sanderson, Barbara Joanne; Wang, Jing J; Wang, HeItem RZF, a zinc-finger protein in the photoreceptors of human retina(2004) Higginson, K A; Sharma, Shiwani; Della, N G; Dimasi, David PaulItem Myocilin allele-specific glaucoma phenotype database(2008) Craig, Jamie E; Hewitt, Alex W; Mackey, David AItem Genetics and breeding in seed supply for inland aquaculture(Food and Agriculture Organization of the United Nations (FAO), 2007) Mair, Graham CharlesItem DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease(2008) Porta, Silvia; Arbones, Maria L; Keating, Damien John; Dubach, Daphne; Zanin, Mark Phillip; Yu, Yong; Martin, Katherine; Zhao, Yu-Feng; Chen, Chen; Mittaz, Laureane; Pritchard, Melanie AItem The genome sequence of the filamentous fungus Neurospora crassa(2003) Butler, Jonathan; Endrizzi, Matthew; Qui, Dayong; Ianakiev, Peter; Bell-Pedersen, Deborah; Nelson, Mary Anne; Werner-Washburne, Margaret; Selitrennikoff, Claude P; Kinsey, John A; Braun, Edward L; Krystofova, Svetlana; Rasmussen, Carolyn; Metzenberg, Robert L; Perkins, David D; Kroken, Scott; Calvo, Sarah E; Galagan, James E; Borkovich, Katherine A; Selker, Eric U; Jaffe, David; FitzHugh, William; Ma, Li-Jun; Smirnov, Serge; Purcell, Seth; Rehman, Bushra; Elkins, Timothy; Engels, Reinhard; Wang, Shunguang; Nielsen, Cydney B; Zelter, Alex; Schulte, Ulrich; Kothe, Gregory O; Jedd, Gregory; Read, Nick D; Mewes, Werner; Staben, Chuck; Marcotte, Edward; Greenberg, David; Roy, Alice; Foley, Karen; Naylor, Jerome R; Stange-Thomann, Nicole; Barrett, Robert; Kamal, Michael; Kamvysselis, Manolis; Mauceli, Evan; Bielke, Cord; Rudd, Stephen; Frishman, Dmitrij; Cogoni, Carlo; Macino, Giuseppe; Gnerre, Sante; Catcheside, David Edward; Li, Weixi; Pratt, Robert J; Osmani, Stephen A; DeSouza, Colin P C; Glass, Louise; Berglund, J Andrew; Voelker, Rodger; Yarden, Oded; Plamann, Michael; Seiler, Stephan; Dunlap, Jay C; Orbach, Marc J; Radford, Alan; Aramayo, Rodolfo; Natvig, Donald O; Alex, Lisa A; Mannhaupt, Gertrud; Freitag, Michael; Paulsen, Ian T; Sachs, Matthew S; Lander, Eric S; Nusbaum, Chad; Birren, Bruce; Ebbole, Daniel JItem Integrative analysis of RUNX1 downstream pathways and target genes(2008) Michaud, Joelle; Simpson, Ken; Escher, Robert; Buchet-Poyau, Karine; Beissbarth, Tim; Carmichael, Catherine; Ritchie, Matthew E; Schutz, Frederic; Cannon, Ping; Liu, Marjorie; Shen, Xiaofeng; Ito, Yoshiaki; Raskind, Wendy H; Horwitz, Marshall S; Turner, David Richard; Speed, Terence P; Kavallaris, Maria; Smyth, Gordon K; Scott, Hamish S; Osato, MotomiBackground The RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It is also responsible for a familial platelet disorder with predisposition to acute myeloid leukemia (FPD-AML). The disruption of the largely unknown biological pathways controlled by RUNX1 is likely to be responsible for the development of leukemia. We have used multiple microarray platforms and bioinformatic techniques to help identify these biological pathways to aid in the understanding of why RUNX1 mutations lead to leukemia. Results Here we report genes regulated either directly or indirectly by RUNX1 based on the study of gene expression profiles generated from 3 different human and mouse platforms. The platforms used were global gene expression profiling of: 1) cell lines with RUNX1 mutations from FPD-AML patients, 2) over-expression of RUNX1 and CBFβ, and 3) Runx1 knockout mouse embryos using either cDNA or Affymetrix microarrays. We observe that our datasets (lists of differentially expressed genes) significantly correlate with published microarray data from sporadic AML patients with mutations in either RUNX1 or its cofactor, CBFβ. A number of biological processes were identified among the differentially expressed genes and functional assays suggest that heterozygous RUNX1 point mutations in patients with FPD-AML impair cell proliferation, microtubule dynamics and possibly genetic stability. In addition, analysis of the regulatory regions of the differentially expressed genes has for the first time systematically identified numerous potential novel RUNX1 target genes. Conclusion This work is the first large-scale study attempting to identify the genetic networks regulated by RUNX1, a master regulator in the development of the hematopoietic system and leukemia. The biological pathways and target genes controlled by RUNX1 will have considerable importance in disease progression in both familial and sporadic leukemia as well as therapeutic implications.Item Chromosome pairing and meiotic recombination in Neurospora crassa spo11 mutants(2006) Bowring, Frederick James; Yeadon, Patricia Jane; Stainer, Russell Grantley; Catcheside, David EdwardItem Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people(2008) Baird, Paul N; Wang, Jie Jin; Mackey, David A; Mitchell, Paul; Sharma, Shiwani; Burdon, Kathryn Penelope; Hewitt, Alex W; Dimasi, David Paul; Craig, Jamie EItem Molecular phylogenetics of the allodapine bee genus Braunsapis: A-T bias and heterogeneous substitution parameters(2004) Tierney, Simon M; Schwarz, Michael Philip; Bull, N J; Cooper, Steven J BItem Origins of social parasitism: the importance of divergence ages in phylogenetic studies(2007) Schwarz, Michael Philip; Smith, Jaclyn Amanda; Tierney, Simon M; Park, Yung Chul; Fuller, Susan JItem Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities(2008) Dubach, Daphne; Finkelstein, David I; Pritchard, Melanie A; Tkalcevic, Josephine; Yu, Yong; Chu, Po-Yin; Harper, Ian; Bowser, David N; Keating, Damien JohnItem Sequence heterology and gene conversion at his-3 in Neurospora crassa(2004) Yeadon, Patricia Jane; Bowring, Frederick James; Catcheside, David EdwardItem Complete sequencing and analysis of pEN2701, a novel 13-kb plasmid from an endophytic Streptomyces sp.(2003) Franco, Christopher Milton; Coombs, J T; Loria, Rosemary
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