0305 - Organic Chemistry
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This collection contains Flinders' research in Organic Chemistry, as reported for ERA 2012.
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Item Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives(MDPI, 2015-04-13) Gleeson, Ellen C; Graham, Janease E; Spiller, Sandro; Vetter, Irina; Lewis, Richard J; Duggan, Peter; Tuck, Kellie LA set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel is a validated target for the treatment of refractory chronic pain. Despite being significantly less complex than the originally designed mimetics, up to a seven-fold improvement in activity was observed.Item Bioactive mimetics of conotoxins and other venom peptides(MDPI, 2015-10-16) Duggan, Peter; Tuck, Kellie LZiconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode of delivery and narrow therapeutic window cause complications for patients. This review will summarize progress in the development of small molecule, non-peptidic mimics of Conotoxins and a small number of other venom peptides. This will include a description of how some of the initially designed mimics have been modified to improve their drug-like properties.Item A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors(2010) Khalafy, Jabbar; Pesyan, Nader Noroozi; Prager, Rolf Herman; Rimaz, MehdiItem Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, a-phthalimidopropiophenone and N-ethylcathinone(2010) Camilleri, Andrew; Johnston, Martin Ross; Brennan, Michael; Davis, Sean; Caldicott, DavidItem Bio-fuels(Routledge, 2010) Clarke, Stephen; Graiver, Daniel; Habibie, SudirmanItem Gas-phase facial diastereoselectivity of equatorial and axial 4-chloro-adamant-2-yl cations(2009) Fraschetti, Caterina; Novara, Francesca; Filippi, Antonella; Speranza, Maurizio; Trout, Neil Alan; Marcantoni, Enrico; Renzi, Gabriele; Roselli, Graziella; Adcock, William; Marcolini, MauroItem N,N-Dialkyl-N'-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part VIII.* Novel Pyrazolo-Fused Oxathiadiazines and Thiatriazoles(2010) Francis, Craig; Young, Anna Penan; Liepa, Andris; Forsyth, Craig; Jahangiri, Saba; Perkins, Michael VictorItem The synthesis of potential DNA intercalators. Part 3. Triazanaphthalene, tetraaza-anthracenes and phenanthrenes from isoxazolones(2009) Marjani, Ahmad Poursattar; Ebrahimlo, Ali Reza; Khalafy, Jabbar; Prager, Rolf HermanItem Enantioselective Synthesis of {alpha}-Fluoro-{beta}-amino Esters: Synthesis of Enantiopure, Orthogonally Protected{alpha}-Fluoro-{beta}-lysine(2010) Johnston, Martin Ross; March, Taryn Lee; Duggan, PeterItem The Synthesis of Potential DNA Intercalators. 2. Tri- and Tetra-Cyclic Heterocycles*(2009) Ebrahimlo, Ali Reza; Khalafy, Jabbar; Prager, Rolf HermanItem N,N-Dialkyl-N'-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part IX.* Novel Triazolo-Fused Thiatriazoles and Pyrazolo-Fused Oxathiazines(2010) Jahangiri, Saba; Liepa, Andris; Perkins, Michael Victor; Young, Anna Penan; Forsyth, Craig; Francis, CraigItem The Synthesis and Characterisation of a Free-Base Porphyrin-Perylene Dyad that Exhibits Electronic Coupling in Both the Ground and Excited States(2009) Mathew, Simon; Johnston, Martin RossItem Nature of transmission of polar substituent effects in {gamma}-disposed bicyclo[2.2.1]heptane (norbornane) and adamantane ring systems as monitored by 19F NMR: A DFT- GIAO and - NBO analysis(2009) Schamschurin, Andrew; Adcock, William; Taylor, Julian F.Item Optimizing properties of polypropylene and elastomer compounds containing wood flour(Springer, 2009) Budin, Jan; Clarke, Stephen; Spiridonov, Pavel; Matisons, JanisItem 3-Chloro,4-methoxyfendiline is a potent GABAB receptor potentiator in rat neocortical slices(2005) Marino, Victor; Kerr, David I B; Ong, Jennifer; Puspawati, Ni Made; Parker, David A S; Prager, Rolf HermanItem Three-centre hydrogen bonding in the complexes of syn-2,4-difluoroadamantane with 4-fluorophenol and hydrogen fluoride(2005) Adcock, William; Graton, Jerome; Laurence, Christian; Lucon, Maryvonne; Trout, Neil AlanItem Synthesis of the Individual Diastereomers of the Cysteine Conjugate of 3-Mercaptohexanol (3-MH)(2008) Pardon, Kevin H; Graney, Sean Damien; Capone, Dimitra; Swiegers, Jan; Sefton, Mark; Elsey, Gordon MichaelItem Synthesis of the Putative Structure of Tridachiahydropyrone(2005) Jeffery, David William; Perkins, Michael Victor; White, J MItem Generation of (E)-1-(2,3,6-Trimethylphenyl)buta-1,3-diene from C13-Norisoprenoid Precursors(2005) Cox, Agnieszka; Skouroumounis, George; Elsey, Gordon Michael; Perkins, Michael Victor; Sefton, Mark
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