ItemThe Nonserotypeable Pneumococcus: Phenotypic Dynamics in the Era of Anticapsular Vaccines(2010) Marsh, Robyn L; Smith-Vaughan, H; Hare, Kim; Binks, Michael J; Kong, Fanrong; Warning, Julia; Gilbert, Gwendolyn L; Morris, Peter Stanley; Leach, Amanda J ItemSeeking treatment for symptomatic malaria in Papua New Guinea(2010) Davy, Carol; Sicuri, E; Ome, Maria; Lawrence-Wood, Eleanor Ruth; Siba, Peter; Mueller, Ivo; Warvi, Gordon; Conteh, Lesong ItemIncreased transcription of Glutathione S-transferases in acaricide exposed scabies mites(2010) Arlian, Larry G; Morgan, Marjorie S; Holt, Deborah C; Currie, Bart John; Mounsey, Kate E; Pasay, Cielo J; Walton, Shelley F; McCarthy, James ItemSwab transport in Amies gel followed by frozen storage in skim milk tryptone glucose glycerol broth (STGGB) for studies of respiratory bacterial pathogens(2010) Morris, Peter Stanley; Hare, Kim; Stubbs, E; Beissbarth, Jemima; Leach, Amanda J ItemCommunity-acquried Klebsiella pneumoniae liver abscesses - an emerging disease in Australia(2010) Maiwald, Matthias Gotthard; Gordon, David Llewellyn; Anstey, James R; Fazio, Timothy N; Hogg, Geoff; Jenney, Adam W; Wilksch, Jonathan J. ItemRegulation of epithelial apical junctions and barrier function by Ga13(2009) Abbott, Catherine Anne; Wood, Stephen A; Donato, Rino; Saunders, Ian; Gundsambuu, Batjargal; Mak, Kai Yan; Powell, Barry Crampton ItemAlbomycin is an effective antibiotic, as exemplified with Yersinia enterocolitica and Streptococcus pneumoniae.(2007) Pramanik, Avijit; Standish, Alister; Braun, Volkmar; Paton, James Cleland; Stroeher, Uwe Horst; Autenrieth, Ingo; Bohn, Erwin; Krejci, Juliana ItemApplication of an allele specific PCR to clinical HIV genotyping samples detects additional K103N mutations in both therapy naïve and experienced patients(2009) Higgins, Geoffrey; Burrell, Christopher; Qiao, Ming; Carr, Jill; Green, Tara; Shaw, David; Daly, Lyndal; Hart, Wendy; Ratcliff, Rodney; Li, Peng ItemRandom colony selection versus colony morphology for detection of multiple pneumococcal serotypes in nasopharyngeal swabs.(2008) Hare, Kim; Smith-Vaughan, Heidi; Leach, Amanda Jane; Morris, Peter Stanley ItemAustralian and Thai isolates of Burkholderia pseudomallei are distinct by multilocus sequence typing: revision of a case of mistaken identity(2007) Currie, Bart John; Ward, Linda Maree; Thomas, Annette D; Godoy, Daniel; Dance, David A B; Cheng, Allen C; Mayo, Mark J; Pitt, Tyrone L; Spratt, Brian G ItemThe relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.(2008) Lee, Sue; Stepniewska, Kasia; Anstey, Nicholas Mark; Ashley, Elizabeth; Barnes, Karen; Binh, Tran Quang; D'Alessandro, Umberto; Day, Nicholas P J; de Vries, Peter J; Dorsey, Grant; Guthmann, Jean-Paul; Mayxay, Mayfong; Newton, Paul N; Nosten, Francois; Olliaro, Piero; Osario, Lyda; Pinoges, Loretxu; Price, Richard; Rowland, Mark; Smithuis, Frank; Taylor, Robert; White, Nicholas James ItemGenetic diversity of Burkholderia pseudomallei Isolates in Australia(2008) Spratt, Brian G; Ward, Linda Maree; Currie, Bart John; Godoy, Daniel; Norton, R; Mayo, Mark J; Gal, Daniel; Cheng, Allen C ItemRole of cellular glycosaminoglycans and charged regions of viral G protein in human metapneumovirus infection(2008) Thammawat, Sutthiwan; Sadlon, Tania; Hallsworth, Peter Gordon; Gordon, David Llewellyn ItemComparison of nasal swabs with nose blowing for community-based pneumococcal surveillance of healthy children.(2008) Morris, Peter Stanley; Stubbs, Elizabeth; Beissbarth, Jemima; Hare, Kim; Leach, Amanda Jane ItemAnalysis of the first Australian strains of Bartonella quintana reveals unique genotypes(2007) Woolley, Mark; Wetherall, Bruce Lawrence; Gordon, David Llewellyn ItemBurkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis(2005) Day, Nicholas P J; Mayo, Mark J; Gal, Daniel; Currie, Bart John; Cheng, Allen C ItemEmergence and spread of rifampicin-resistant, methicillin-resistant Staphylococcus aureus during vancomycin-rifampicin combination therapy in an intensive care unit(2006) Ju, Oui; Woolley, Mark; Gordon, David Llewellyn ItemMannose-binding lectin deficiency does not increase the prevalence of Helicobacter pylori seropositivity(2007) Worthley, Daniel L; Mullighan, Charles G; Dean, Melinda M Phillips, Peter; Gordon, David Llewellyn; Phillips, Paddy Andrew; Heatley, Susan; Young, Graeme Paul; Bardy, Peter GBackground Mannose-binding lectin is an immune molecule that can bind to pathogens and initiate the complement cascade. In certain clinical situations, often characterized by immune compromise, mannose-binding lectin deficiency can increase the risk of infectious complications. Helicobacter pylori is one of the most common human infections and can bind mannose-binding lectin. Therefore, we examined whether mannose-binding lectin status influences the prevalence of H. pylori infection. Methods Two distinct populations were targeted. The first consisted of 166 volunteer blood donors, the second included 108 peripheral blood stem cell donors. All were tested for serological evidence of H. pylori infection, and had their mannose-binding lectin status characterized by genotyping, and quantification of mannose-binding lectin mannan-binding level and C4-deposition function in plasma. Results H. pylori positive blood donors had higher blood mannose-binding lectin levels, as measured by C4 deposition (median 0.67 vs. 0.40, P=0.009, hazard ratio 2.82, 95% confidence interval 1.29–6.19) and mannan-binding assays (median 1.83 vs. 1.26, P=0.02, hazard ratio 1.28, 95% confidence interval 1.03–1.59). A trend was also found between the presence of an MBL2 coding mutation and a reduced prevalence of H. pylori. No significant associations were found in the second population. Conclusions Mannose-binding lectin deficiency does not increase the risk of H. pylori infection. The finding in one population that greater mannose-binding lectin activity might predispose to infection, suggests that this study should be repeated in other large cohorts of normal subjects.