11 - Medical and Health Sciences

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This community contains Flinders' research in Medical and Health Sciences that has been collected for ERA 2012.

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Browsing 11 - Medical and Health Sciences by Subject "0205 Optical Physics"

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    Impact of Zernike-fit error on simulated high- and low-contrast acuity in keratoconus: implications for using Zernike-based-corrections
    (2006) Marsack, Jason D; Pesudovs, Konrad; Sarver, Edwin J; Applegate, Raymond A
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    Three-dimensional relationship between high-order root-mean-square wavefront error, pupil diameter, and aging
    (2007) Koenig, Darren E; Applegate, Raymond A; Donnelly, William J; Marsack, Jason D; Pesudovs, Konrad
    We report root-mean-square (RMS) wavefront error (WFE) for individual aberrations and cumulative highorder (HO) RMS WFE for the normal human eye as a function of age by decade and pupil diameter in 1 mm steps from 3 to 7 mm and determine the relationship among HO RMS WFE, mean age for each decade of life, and luminance for physiologic pupil diameters. Subjects included 146 healthy individuals from 20 to 80 years of age. Ocular aberration was measured on the preferred eye of each subject (for a total of 146 eyes through dilated pupils; computed for 3, 4, 5, 6, and 7 mm pupils; and described with a tenth-radial-order normalized Zernike expansion. We found that HO RMS WFE increases faster with increasing pupil diameter for any given age and pupil diameter than it does with increasing age alone. A planar function accounts for 99% of the variance in the 3-D space defined by mean log HO RMS WFE, mean age for each decade of life, and pupil diameter. When physiologic pupil diameters are used to estimate HO RMS WFE as a function of luminance and age, at low luminance 9 cd/m2 HO RMS WFE decreases with increasing age. This normative data set details (1) the 3-D relationship between HO RMS WFE and age for fixed pupil diameters and (2) the 3-D relationship among HO RMS WFE, age, and luminance for physiologic pupil diameters.