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Browsing College of Medicine and Public Health by Author "Abou-Saleh, Haissam"
Systemic sclerosis (SSc), an autoimmune disease that is associated with a number
of genetic and environmental risk factors, is characterized by progressive fibrosis and
microvasculature damage in the skin, lungs, heart, digestive system, kidneys, muscles,
joints, and nervous system. These abnormalities are associated with altered secretion of
growth factor and profibrotic cytokines, such as transforming growth factor-beta (TGF-b),
interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective-tissue growth
factor (CTGF). Among the cellular responses to this proinflammatory environment, the
endothelial cells phenotypic conversion into activated myofibroblasts, a process known
as endothelial tomesenchymal transition (EndMT), has been postulated. Reactive oxygen
species (ROS) might play a key role in SSs-associated fibrosis and vascular damage
by mediating and/or activating TGF-b-induced EndMT, a phenomenon that has been
observed in other disease models. In this review, we identified and critically appraised
published studies investigating associations ROS and EndMT and the presence of
EndMT in SSc, highlighting a potential link between oxidative stress and EndMT in this