Our teaching footprint reaches out from our world class teaching hospital at the Flinders Medical Centre in South Australia to multiple rural clinical locations all the way to Darwin in the Northern Territory.
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This approach has seen us investigate everything from community health problems to the smallest of molecules that influence human disease.
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Browsing College of Medicine and Public Health by Author "Abell, Andrew D"
(Royal Society of Chemistry, 2016-01-26) Cottam Jones, Jade M; Harris, Paul William Richard; Scanlon, Denis B; Forbes, Briony E; Brimble, Margaret Anne; Abell, Andrew D
The interaction of IGF-II with the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF-1R) has recently been identified as potential therapeutic target for the treatment of cancer. Understanding the interactions of IGF-II with these receptors is required for the development of potential anticancer therapeutics. This work describes an efficient convergent synthesis of native IGF-II and two nonnative IGF-II analogues with coumarin fluorescent probes incorporated at residues 19 and 28. These fluorescent analogues bind with nanomolar affinities to the IGF-1R and are suitable for use in fluorescence resonance energy transfer (FRET) studies. From these studies the F19Cou IGF-II and F28Cou IGF-II proteins were identified as good probes for investigating the binding interactions of IGF-II with the IGF-1R and its other high affinity binding partners.