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Browsing Computer Science, Engineering and Mathematics by Author "Akraa, Shaymaa"
(Elsevier, 2018-04-23) Akraa, Shaymaa; Pham, Tran Tam Anh; Shen, Haifeng; Tang, Youhong; Tang, Ben Zhong; Li, Jimmy Siu; Walker, Sandy
This paper presents the design and development of a smartphone-based urinalysis device that has the ability for chronic
kidney disease (CKD) patients themselves to conduct rapid and reliable quantitative urinalysis of human serum albumin
(HSA) using an aggregation-induced emission (AIE) nanomaterial bioprobe with their own smartphones. The focus of
this paper is a novel solution to the device agnosticism issue as a wide diversity of smartphones co-exist in the market. The
solution comprises: a) custom-design and fabrication of an imaging housing that provides a consistent imaging condition
regardless of the physical dimensions and the camera position of the smartphone used, b) orchestration of an image
processing and analysis process that produces consistent image colour intensity values regardless of the camera sensor
and imaging software used by the smartphone, and c) special design and development of an intuitive cross-platform
mobile application that is scalable to growth, adaptable to changes, resilient to loss of data, and has an extremely
low requirement for smartphone hardware. Preliminary evaluation of the device has confirmed the effectiveness of the
proposed solution and the viability of such a smartphone-based device for people who have already developed or are
prone to CKD to regularly perform point-of-care (POC) urine testing in order to self monitor their own health conditions
without the burden of frequent visits to their doctors.