Preproglucagon neurons innervate neurochemically identified autonomic neurons in the mouse brainstem

dc.contributor.authorLlewellyn-Smith, Ida Jonassen
dc.contributor.authorGnanamanickam, Greta J E
dc.contributor.authorReimann, Frank
dc.contributor.authorGribble, Fiona M
dc.contributor.authorTrapp, Stefan
dc.date.accessioned2013-08-26T04:52:36Z
dc.date.available2013-08-26T04:52:36Z
dc.date.issuedJan-13
dc.date.issued2013-01-01
dc.descriptionThis article appeared in a journal published by Elsevier Ltd. Under Elsevier's copyright, mandated authors are not permitted to make work available in an institutional repository.en
dc.description.abstractPreproglucagon (PPG) neurons produce glucagon-like peptide-1 (GLP-1) and occur primarily in the nucleus tractus solitarius (NTS). GLP-1 affects a variety of central autonomic circuits, including those controlling the cardiovascular system, thermogenesis, and most notably energy balance. Our immunohistochemical studies in transgenic mice expressing YFP under the control of the PPG promoter showed that PPG neurons project widely to central autonomic regions, including brainstem nuclei. Functional studies have highlighted the importance of hindbrain receptors for the anorexic effects of GLP-1.en
dc.description.sponsorshipAustralian National Health & Medical Research Councilen
dc.identifier.citationLlewellyn-Smith, I.J.,Gnanamanickam, G.J.E., Reimann, F., Gribble, F.M. and Trapp, S., 2013. Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem. Neuroscience, 229, 130-143.en
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2012.09.071en
dc.identifier.issn0306-4522
dc.identifier.urihttp://hdl.handle.net/2328/26998
dc.language.isoenen_US
dc.publisherElsevieren
dc.relationhttp://purl.org/au-research/grants/nhmrc/480414
dc.relationhttp://purl.org/au-research/grants/nhmrc/1025031
dc.relation.grantnumberNHMRC/480414
dc.relation.grantnumberNHMRC/1025031
dc.rightsCopyright 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
dc.rights.holderElsevier Ltd.
dc.subjectMetabolism
dc.subjectNeural pathways
dc.subjectNeurons
dc.titlePreproglucagon neurons innervate neurochemically identified autonomic neurons in the mouse brainstemen_US
dc.typeArticleen
local.contributor.authorOrcidLookupLlewellyn-Smith, Ida Jonassen: https://orcid.org/0000-0003-4269-6846en_US
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