Preproglucagon neurons innervate neurochemically identified autonomic neurons in the mouse brainstem
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Date
Jan-13, 2013-01-01
Authors
Llewellyn-Smith, Ida Jonassen
Gnanamanickam, Greta J E
Reimann, Frank
Gribble, Fiona M
Trapp, Stefan
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Rights
Copyright 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
Rights Holder
Elsevier Ltd.
Abstract
Preproglucagon (PPG) neurons produce glucagon-like peptide-1 (GLP-1) and occur primarily in the nucleus tractus solitarius (NTS). GLP-1 affects a variety of central autonomic circuits, including those controlling the cardiovascular system, thermogenesis, and most notably energy balance. Our immunohistochemical studies in transgenic mice expressing YFP under the control of the PPG promoter showed that PPG neurons project widely to central autonomic regions, including brainstem nuclei. Functional studies have highlighted the importance of hindbrain receptors for the anorexic effects of GLP-1.
Description
This article appeared in a journal published by Elsevier Ltd. Under Elsevier's copyright, mandated authors are not permitted to make work available in an institutional repository.
Keywords
Metabolism, Neural pathways, Neurons
Citation
Llewellyn-Smith, I.J.,Gnanamanickam, G.J.E., Reimann, F., Gribble, F.M. and Trapp, S., 2013. Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem. Neuroscience, 229, 130-143.